8-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione -Drug Synthesis Database

【结构式】

【分子编号】43485

【品名】8-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

【CA登记号】

【分子式】C₂₁H₂₆N₄O₄

【分子量】398.462

【元素组成】C 63.3% H 6.58% N 14.06% O 16.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

This compound has been obtained by methylation of 1,3-diethyl-8-[2(E)-(4-hydroxy-3-methoxyphenyl)vinyl]-7-methylxanthine (I) (KF-23325) with 11C methyl iodide and NaOH in DMF.

参考文献中间体

合成目标

【1】 Brady, F.; Luthra, S.K.; Shimada, J.; Karasawa, A.; Brooks, D.J.; Gillies, J.; Kase, H.; Radiolabelling of KW-6002 with [11C]iodomethane for studies of the adenosine A2A receptor in vivo. J Label Compd Radiopharm 1999, 42, Suppl. 1, S456.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43485	8-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione		C₂₁H₂₆N₄O₄	详情	详情

Extended Information