ethyl 3-(4-hydroxy-3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)propanoate -Drug Synthesis Database

【结构式】

【分子编号】43480

【品名】ethyl 3-(4-hydroxy-3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)propanoate

【CA登记号】

【分子式】C₁₆H₂₁NO₄

【分子量】291.34708

【元素组成】C 65.96% H 7.27% N 4.81% O 21.97%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXXII)

Quinolinone (XXVIII) was also obtained by reduction of quinoline dione (XXXI) to alcohol (XXXII), followed by esterification to acetate (XXXIII) and hydrogenolysis of the acetoxy group in the presence of palladium oxide.

参考文献中间体

合成目标

【1】 Smith, G.P.; Brundish, D.E.; Menear, K.A.; Walker, C.V.; Herold, P.; Fullerton, J.D.; Allen, M.C.; Le Grand, D.M.; Kane, P.D.; Cockcroft, X.-L.; Wathey, W.B.; Butler, P.I.; Hatto, J.D.I.; Hayler, J.D. (Novartis AG); Tetrahydroquinoline inhibitors of trypsin and thrombin. GB 2312674 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XXVIII)	43476	ethyl 3-(3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)propanoate	C₁₆H₂₁NO₃	详情	详情
(XXXI)	43479	ethyl 3-(3,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-6-quinolinyl)propanoate	C₁₆H₁₉NO₄	详情	详情
(XXXII)	43480	ethyl 3-(4-hydroxy-3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)propanoate	C₁₆H₂₁NO₄	详情	详情
(XXXIII)	43481	ethyl 3-[4-(acetoxy)-3,3-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl]propanoate	C₁₈H₂₃NO₅	详情	详情

Extended Information