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【结 构 式】 
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【分子编号】43326 【品名】N-(3,4-difluorobenzyl)-N-(dibenzylene)amine; (3,4-difluorophenyl)-N-(dibenzylene)methanamine 【CA登记号】 |
【 分 子 式 】C20H15F2N 【 分 子 量 】307.3426464 【元素组成】C 78.16% H 4.92% F 12.36% N 4.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)In an alternative procedure, 3,4-difluorobenzylamine (X) was condensed with benzophenone in the presence of a catalytic amount of boron trifluoride etherate to afford imine (XI). After deprotonation of (XI) with tert-butyllithium, its condensation with acetaldehyde produced a protected amino alcohol, which was then deprotected by treatment with O-methyl hydroxylamine. The resulting amino alcohol (VI) was converted to oxazolidine (IX) by the same method as above.
| 【1】 Tian, D.; Jeon, Y.; Lagu, B.; et al.; De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. J Med Chem 2000, 43, 15, 2775. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 43321 | 1-amino-1-(3,4-difluorophenyl)-2-propanol | C9H11F2NO | 详情 | 详情 | |
| (X) | 43325 | 3,4-difluorobenzylamine; (3,4-difluorophenyl)methanamine | 72235-53-1 | C7H7F2N | 详情 | 详情 |
| (XI) | 43326 | N-(3,4-difluorobenzyl)-N-(dibenzylene)amine; (3,4-difluorophenyl)-N-(dibenzylene)methanamine | C20H15F2N | 详情 | 详情 |
Extended Information