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【结 构 式】 
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【分子编号】43322 【品名】tert-butyl 1-(3,4-difluorophenyl)-2-hydroxypropylcarbamate 【CA登记号】 |
【 分 子 式 】C14H19F2NO3 【 分 子 量 】287.3066064 【元素组成】C 58.53% H 6.67% F 13.23% N 4.88% O 16.71% |
合成路线1
该中间体在本合成路线中的序号：(VII)The addition of ethylmagnesium bromide to 3,4-difluorobenzaldehyde (I) gave alcohol (II), which was oxidized to ketone (III) by using pyridinium chlorochromate. Treatment of (III) with iodobenzene diacetate in methanolic KOH produced the hydroxy ketone (IV). This was converted to oxime (V) and subsequently reduced with LiAlH4, yielding amino alcohol (VI) as a mixture of diastereoisomers. The mixture of amino alcohols (VI) was treated with Boc2O to afford carbamate (VII), which was then cyclized in the presence of NaH in THF. The resulting diastereomeric mixture of oxazolidinones (VIII) was first separated by column chromatography, and the racemic trans-isomer was then resolved by means of chiral HPLC to provide the required (+)-trans-oxazolidine (IX).
| 【1】 Broten, T.P.; Nichtberger, S.A.; Siegl, P.K.S. (Merck & Co., Inc.); Combination therapy for the treatment of benign prostatic hyperplasia. WO 9948530 . |
| 【2】 Marzabadi, M.R.; Wong, W.C.; Gluchowski, C.; Tian, D.; Nagarathnam, D.; Lagu, B.; Dhar, T.G.M.; Jeon, Y.T. (Synaptic Pharmaceutical Corp.); Heterocyclic substd. piperidines and uses thereof. EP 0988295; WO 9857940 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26654 | 3,4-difluorobenzaldehyde | 34036-07-2 | C7H4F2O | 详情 | 详情 |
| (II) | 43317 | 1-(3,4-difluorophenyl)-1-propanol | C9H10F2O | 详情 | 详情 | |
| (III) | 43318 | 1-(3,4-difluorophenyl)-1-propanone | 23384-72-7 | C9H8F2O | 详情 | 详情 |
| (IV) | 43319 | 1-(3,4-difluorophenyl)-2-hydroxy-1-propanone | C9H8F2O2 | 详情 | 详情 | |
| (V) | 43320 | 1-(3,4-difluorophenyl)-2-hydroxy-1-propanone oxime | C9H9F2NO2 | 详情 | 详情 | |
| (VI) | 43321 | 1-amino-1-(3,4-difluorophenyl)-2-propanol | C9H11F2NO | 详情 | 详情 | |
| (VII) | 43322 | tert-butyl 1-(3,4-difluorophenyl)-2-hydroxypropylcarbamate | C14H19F2NO3 | 详情 | 详情 | |
| (VIII) | 43323 | 4-(3,4-difluorophenyl)-5-methyl-1,3-oxazolidin-2-one | C10H9F2NO2 | 详情 | 详情 | |
| (IX) | 43324 | (4S,5S)-4-(3,4-difluorophenyl)-5-methyl-1,3-oxazolidin-2-one | C10H9F2NO2 | 详情 | 详情 |