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【结 构 式】 
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【分子编号】43199 【品名】3-nitrophenyl 2-quinolinylmethyl ether; 2-[(3-nitrophenoxy)methyl]quinoline 【CA登记号】 |
【 分 子 式 】C16H12N2O3 【 分 子 量 】280.28296 【元素组成】C 68.56% H 4.32% N 9.99% O 17.12% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of 2-(chloromethyl)quinoline (I) with 3-nitrophenol (II) by means of Cs2CO3 in refluxing acetone gives the 3-nitrophenyl ether (III), which is reduced with H2 over Raney-Ni in ethanol to afford the 3-aminophenyl ether (IV). Finally this compound is sulfonated with trifluoromethanesulfonic anhydride and Et3N in dichloromethane.
| 【1】 Kreft, A.; Musser, J.; Substituted-[2-quinolynil(bridged)aryl] compounds: modulators of eicosanoid biosynthesis and action. Drugs Fut 1990, 15, 1, 73. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13162 | 2-(Chloromethyl)quinoline; alpha-Chloroquinaldine | 4377-41-7 | C10H8ClN | 详情 | 详情 |
| (II) | 18076 | Metanitrophenol; 3-nitrophenol | 554-84-7 | C6H5NO3 | 详情 | 详情 |
| (III) | 43199 | 3-nitrophenyl 2-quinolinylmethyl ether; 2-[(3-nitrophenoxy)methyl]quinoline | C16H12N2O3 | 详情 | 详情 | |
| (IV) | 31234 | 3-(2-quinolinylmethoxy)aniline; 3-(2-quinolinylmethoxy)phenylamine | C16H14N2O | 详情 | 详情 |
Extended Information