1-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenyl-4-piperidinecarbonitrile -Drug Synthesis Database

【结构式】

【分子编号】43078

【品名】1-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenyl-4-piperidinecarbonitrile

【CA登记号】

【分子式】C₂₃H₂₃N₃O₂

【分子量】373.45464

【元素组成】C 73.97% H 6.21% N 11.25% O 8.57%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The intermediate amine (IV) was prepared by alkylation of 4-cyano-4-phenylpiperidine (I) with N-(3-bromopropyl)phthalimide (II), followed by hydrazinolysis of the substituted phthalimide (III).

参考文献中间体

合成目标

【1】 Wong, W.C.; Lagu, B.; Nagarathnam, D.; Marzabadi, M.R.; Gluchowski, C. (Synaptic Pharmaceutical Corp.); Dihydropyrimidines and uses thereof. EP 1021185; JP 2000506904; WO 9742956 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43077	4-phenyl-4-piperidinecarbonitrile	40481-13-8	C₁₂H₁₄N₂	详情	详情
(II)	15216	N-(3-Bromopropyl)phthalimide; 2-(3-bromopropyl)-1H-isoindole-1,3(2H)-dione	5460-29-7	C₁₁H₁₀BrNO₂	详情	详情
(III)	43078	1-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-4-phenyl-4-piperidinecarbonitrile		C₂₃H₂₃N₃O₂	详情	详情
(IV)	43079	1-(3-aminopropyl)-4-phenyl-4-piperidinecarbonitrile		C₁₅H₂₁N₃	详情	详情

Extended Information