【结 构 式】 |
【分子编号】42934 【品名】(3R,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone 【CA登记号】 |
【 分 子 式 】C11H16N2O2 【 分 子 量 】208.26032 【元素组成】C 63.44% H 7.74% N 13.45% O 15.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)The alkylation of pilosine (I) with ethyl chloride (II) by means of LDA in THF gives trans-pilocarpine (III), which is isomerized with LDA in THF, yielding a mixture of cis- and trans-pilocarpine (IV). Finally, this mixture is resolved by crystallization with di-p-toluoyl tartaric acid.
【1】 Shapiro, G.; Enz, A.; Pilocarpine analogs as muscarinic agonists. Drugs Fut 1992, 17, 6, 489. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 42933 | (4R)-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone | C9H12N2O2 | 详情 | 详情 | |
(II) | 42926 | 1-chloroethane | 75-00-3 | C2H5Cl | 详情 | 详情 |
(III) | 42934 | (3R,4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone | C11H16N2O2 | 详情 | 详情 | |
(IV) | 42935 | (4R)-3-ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydro-2(3H)-furanone | C11H16N2O2 | 详情 | 详情 |
Extended Information