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【结 构 式】

【分子编号】42910

【品名】ethyl 2-[2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]acetate

【CA登记号】

【 分 子 式 】C12H12N2O4

【 分 子 量 】248.23836

【元素组成】C 58.06% H 4.87% N 11.28% O 25.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of isatoic anhydride (I) with glycine ethyl ester (II) gives N-(2-aminobenzoyl)glycine ethyl ester (III), which is cyclized with carbonyldiimidazole (CDI) to yield 2-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)acetic acid ethyl ester (IV). The alkylation of (IV) with 3,4-dichlorobenzyl bromide (V) affords 2-[1-(3,4-dichlorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl]acetic acid ethyl ester (VI), which is finally hydrolyzed in basic medium.

1 Itoh, Y.; Hashimoto, M.; Ao, S.; Notsu, Y.; Novel aldose reductase inhibitors: Synthesis and structure-activity studies of (3-benzyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl)acetic acids. Drugs Fut 1992, 17, 1, 31.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29797 2H-3,1-benzoxazine-2,4(1H)-dione;Isatoic anhydride;4H-3,1-Benzoxazine-2,4(1H)-dione;1,2-Dihydro-4H-3,1-benzoxazine-2,4-dione;1H-benzo[d][1,3]oxazine-2,4-dione 118-48-9 C8H5NO3 详情 详情
(II) 10309 ethyl 2-aminoacetate; Glycine ethyl ester 459-73-4 C4H9NO2 详情 详情
(III) 42909 ethyl 2-[(2-aminobenzoyl)amino]acetate C11H14N2O3 详情 详情
(IV) 42910 ethyl 2-[2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]acetate C12H12N2O4 详情 详情
(V) 42911 4-(bromomethyl)-1,2-dichlorobenzene 18880-04-1 C7H5BrCl2 详情 详情
(VI) 42912 ethyl 2-[1-(3,4-dichlorobenzyl)-2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]acetate C19H16Cl2N2O4 详情 详情
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