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【结 构 式】 
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【分子编号】42861 【品名】(3S,8R,9S,10R,13S,14S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 【CA登记号】 |
【 分 子 式 】C22H30N2O 【 分 子 量 】338.49308 【元素组成】C 78.06% H 8.93% N 8.28% O 4.73% |
合成路线1
该中间体在本合成路线中的序号：(VII)The Vilsmeier-Haack formylation of 3-beta-acetoxyandrost-5-en-17-one (I) with POCl3/DMF provides the desired chloro aldehyde (III) along with minor amounts of the vinyl chloride (II), which are separated by column chromatography. Condensation of (III) with imidazole (IV) by means of K2CO3 in hot DMF yields derivative (V), which by decarbonylation of its 16-formyl group employing a modified Wilkinson’s catalyst gives (VI). The hydrolysis of the acetate group of (VI) with KOH in methanol affords the corresponding alcohol (VII), which is finally oxidized with aluminum isopropoxide and 1-methyl-4-piperidone in refluxing xylene.
| 【1】 Njar, V.C.O.; Grigoryev, D.N.; Long, B.J.; Kato, K.; Brodie, A.M.H.; Nnane, I.P.; Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17alpha-hydroxylase-C17,20-lyase (P45017alpha): Potential agents for the treatment of prostate cancer. J Med Chem 1998, 41, 6, 902. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20083 | Prasterone acetate;3b-Hydroxy-5-androstene-17-one acetate；Dehydroisoandrosterone acetate;Dehydroepiandrosterone 3-acetate;Dehydroepiandrosterone acetate;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | 853-23-6 | C21H30O3 | 详情 | 详情 |
| (II) | 42853 | (3S,8R,9S,10R,13S,14S)-17-chloro-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C21H29ClO2 | 详情 | 详情 | |
| (III) | 42854 | (3S,8R,9S,10R,13S,14S)-17-chloro-16-formyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C22H29ClO3 | 详情 | 详情 | |
| (IV) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (V) | 42859 | (3S,8R,9S,10R,13S,14S)-16-formyl-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C25H32N2O3 | 详情 | 详情 | |
| (VI) | 42860 | (3S,8R,9S,10R,13S,14S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate | C24H32N2O2 | 详情 | 详情 | |
| (VII) | 42861 | (3S,8R,9S,10R,13S,14S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | C22H30N2O | 详情 | 详情 |