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【结 构 式】 
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【分子编号】42852 【品名】tert-butyl (23R,26R)-26-[([(1R)-1-[[(2R)-2-(aminocarbonyl)pyrrolidinyl]carbonyl]-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butyl]amino)carbonyl]-16-benzyl-23-[4-[(tert-butoxycarbonyl)amino]but 【CA登记号】 |
【 分 子 式 】C129H211N25O27S4 【 分 子 量 】2672.51064 【元素组成】C 57.98% H 7.96% N 13.1% O 16.16% S 4.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)Displacement of the bromine of (XIV) with N-Boc-1,6-diaminohexane (XV) produced resin (XVI). Finally, the side-chain protecting groups of (XVI) were cleaved and the desired peptoid was liberated from the resin by treatment with trifluoroacetic acid.
| 【1】 Hamy, F.; et al.; An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication. Proceedings of the National Academy of Sciences of the United States of America 1997, 94, 8, 3548. |
| 【2】 Felder, E.; Hamy, F.; Heizmann, G.; Klimkait, T.; Lazdins, J.K. (Novartis AG); Antiviral peptoid cpds.. EP 0832110; WO 9640759 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 42851 | C118H188BrN23O25S4 | 详情 | 详情 | ||
| (XV) | 31638 | tert-butyl 6-aminohexylcarbamate | 51857-17-1 | C11H24N2O2 | 详情 | 详情 |
| (XVI) | 42852 | tert-butyl (23R,26R)-26-[([(1R)-1-[[(2R)-2-(aminocarbonyl)pyrrolidinyl]carbonyl]-4-[(imino[[(2,2,5,7,8-pentamethyl-3,4,4a,8a-tetrahydro-2H-chromen-6-yl)sulfonyl]amino]methyl)amino]butyl]amino)carbonyl]-16-benzyl-23-[4-[(tert-butoxycarbonyl)amino]but | C129H211N25O27S4 | 详情 | 详情 |
Extended Information