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【结 构 式】

【分子编号】42807

【品名】(2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide

【CA登记号】

【 分 子 式 】C16H30N4O2

【 分 子 量 】310.43996

【元素组成】C 61.9% H 9.74% N 18.05% O 10.31%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

Butylmagnesium bromide (II) was added to the Weinreb amide of Boc-L-leucine (I), yielding ketone (III), which was further reduced with NaBH4 to give alcohol (IV) as a diastereomeric mixture. The Boc protecting group of (IV) was removed employing trifluoroacetic acid in CH2Cl2, and the resulting amino alcohol (V) was coupled with N-Boc-L-histidine (VI) by means of BOP reagent to afford amide (VII). Deprotection of the Boc group of (VII) with trifluoroacetic acid then furnished the target C-terminal fragment (VIII).

1 Cristau, M.; et al.; Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem 2000, 43, 12, 2356.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 40395 tert-butyl (1S)-1-[[methoxy(methyl)amino]carbonyl]-3-methylbutylcarbamate C13H26N2O4 详情 详情
(II) 42802 bromo(butyl)magnesium 693-03-8 C4H9BrMg 详情 详情
(III) 42803 tert-butyl (1S)-1-isobutyl-2-oxohexylcarbamate C15H29NO3 详情 详情
(IV) 42804 tert-butyl (1S)-2-hydroxy-1-isobutylhexylcarbamate C15H31NO3 详情 详情
(V) 42805 (4S)-4-amino-2-methyl-5-nonanol C10H23NO 详情 详情
(VI) 42808 (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-imidazol-5-yl)propionic acid 17791-52-5 C11H17N3O4 详情 详情
(VII) 42806 tert-butyl (1S)-2-[[(1S)-2-hydroxy-1-isobutylhexyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxoethylcarbamate C21H38N4O4 详情 详情
(VIII) 42807 (2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide C16H30N4O2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(VIII)

Deprotection of the benzyl ester group of the N-terminal fragment (XX) by hydrogenolysis provided carboxylic acid (XXI). This was finally coupled with the C-terminal fragment (VIII) employing BOP reagent to furnish the title peptide derivative.

1 Cristau, M.; et al.; Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem 2000, 43, 12, 2356.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VIII) 42807 (2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide C16H30N4O2 详情 详情
(XX) 42815 benzyl 2-[(3S)-3-[((2S)-2-[[(2S)-2-[((2S)-5-amino-2-[[3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl)amino]-2-oxoazepanyl]acetate C43H51N7O9 详情 详情
(XXI) 42816 2-[(3S)-3-[((2S)-2-[[(2S)-2-[((2S)-5-amino-2-[[3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl)amino]-2-oxoazepanyl]acetic acid C36H45N7O9 详情 详情
Extended Information