【结 构 式】 |
【分子编号】42807 【品名】(2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide 【CA登记号】 |
【 分 子 式 】C16H30N4O2 【 分 子 量 】310.43996 【元素组成】C 61.9% H 9.74% N 18.05% O 10.31% |
合成路线1
该中间体在本合成路线中的序号:(VIII)Butylmagnesium bromide (II) was added to the Weinreb amide of Boc-L-leucine (I), yielding ketone (III), which was further reduced with NaBH4 to give alcohol (IV) as a diastereomeric mixture. The Boc protecting group of (IV) was removed employing trifluoroacetic acid in CH2Cl2, and the resulting amino alcohol (V) was coupled with N-Boc-L-histidine (VI) by means of BOP reagent to afford amide (VII). Deprotection of the Boc group of (VII) with trifluoroacetic acid then furnished the target C-terminal fragment (VIII).
【1】 Cristau, M.; et al.; Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem 2000, 43, 12, 2356. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 40395 | tert-butyl (1S)-1-[[methoxy(methyl)amino]carbonyl]-3-methylbutylcarbamate | C13H26N2O4 | 详情 | 详情 | |
(II) | 42802 | bromo(butyl)magnesium | 693-03-8 | C4H9BrMg | 详情 | 详情 |
(III) | 42803 | tert-butyl (1S)-1-isobutyl-2-oxohexylcarbamate | C15H29NO3 | 详情 | 详情 | |
(IV) | 42804 | tert-butyl (1S)-2-hydroxy-1-isobutylhexylcarbamate | C15H31NO3 | 详情 | 详情 | |
(V) | 42805 | (4S)-4-amino-2-methyl-5-nonanol | C10H23NO | 详情 | 详情 | |
(VI) | 42808 | (2S)-2-[(tert-butoxycarbonyl)amino]-3-(1H-imidazol-5-yl)propionic acid | 17791-52-5 | C11H17N3O4 | 详情 | 详情 |
(VII) | 42806 | tert-butyl (1S)-2-[[(1S)-2-hydroxy-1-isobutylhexyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxoethylcarbamate | C21H38N4O4 | 详情 | 详情 | |
(VIII) | 42807 | (2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide | C16H30N4O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(VIII)Deprotection of the benzyl ester group of the N-terminal fragment (XX) by hydrogenolysis provided carboxylic acid (XXI). This was finally coupled with the C-terminal fragment (VIII) employing BOP reagent to furnish the title peptide derivative.
【1】 Cristau, M.; et al.; Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem 2000, 43, 12, 2356. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VIII) | 42807 | (2S)-2-amino-N-[(1S)-2-hydroxy-1-isobutylhexyl]-3-(1H-imidazol-5-yl)propanamide | C16H30N4O2 | 详情 | 详情 | |
(XX) | 42815 | benzyl 2-[(3S)-3-[((2S)-2-[[(2S)-2-[((2S)-5-amino-2-[[3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl)amino]-2-oxoazepanyl]acetate | C43H51N7O9 | 详情 | 详情 | |
(XXI) | 42816 | 2-[(3S)-3-[((2S)-2-[[(2S)-2-[((2S)-5-amino-2-[[3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl)amino]-2-oxoazepanyl]acetic acid | C36H45N7O9 | 详情 | 详情 |