2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol -Drug Synthesis Database

【结构式】

【分子编号】42782

【品名】2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol

【CA登记号】59-02-9

【分子式】C₂₉H₅₀O₂

【分子量】430.7148

【元素组成】C 80.87% H 11.7% O 7.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

By condensation of D-glucopyranuronic acid methyl ester (I) with 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol (III) by means of Tms-OTf.

参考文献中间体

合成目标

【1】 Taraporewala, I.B.; Kauffman, J.M.; Synthesis and structure activity relationships of anti-inflammatory 9,10-dihydro-9-oxo-2-acridine-alkanoic acids and 4-(2-carboxyphenyl)aminobenzenealkanoic acids. J Pharm Sci 1990, 79, 2, 173.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42279	2,2,2-trichloroacetonitrile; Trichloromethylcyanide	545-06-2	C₂Cl₃N	详情	详情
(II)	42780	(trimethylsilyl)[(2S,3R,4S,5R,6S)-3,4,5-tris(acetoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl]oxonium trifluoromethanesulfonate		C₁₇H₂₇F₃O₁₃SSi	详情	详情
(III)	42782	2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol	59-02-9	C₂₉H₅₀O₂	详情	详情

Extended Information