3-butyl-3-ethyl-8-hydroxy-5-phenyl-2,3,4,5-tetrahydro-1H-1lambda(6),4-benzothiazepine-1,1-dione -Drug Synthesis Database

【结构式】

【分子编号】42781

【品名】3-butyl-3-ethyl-8-hydroxy-5-phenyl-2,3,4,5-tetrahydro-1H-1lambda(6),4-benzothiazepine-1,1-dione

【CA登记号】

【分子式】C₂₁H₂₇NO₃S

【分子量】373.51632

【元素组成】C 67.53% H 7.29% N 3.75% O 12.85% S 8.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

By condensation of D-glucopyranuronic acid methyl ester (I) with 3-butyl-3-ethyl-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-ol S,S-dioxide (III) by means of Tms-OTf.

参考文献中间体

合成目标

【1】 Walker, E.H.; Palomino, E.; Blumenthal, S.L.; Carbohydrate prodrugs: potential use for in situ activation and drug delivery. Drugs Fut 1991, 16, 11, 1029.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	42779	methyl (2S,3R,4S,5R,6S)-3,4,5-tris(acetoxy)-6-hydroxytetrahydro-2H-pyran-2-carboxylate	C₁₃H₁₈O₁₀	详情	详情
(II)	42780	(trimethylsilyl)[(2S,3R,4S,5R,6S)-3,4,5-tris(acetoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl]oxonium trifluoromethanesulfonate	C₁₇H₂₇F₃O₁₃SSi	详情	详情
(III)	42781	3-butyl-3-ethyl-8-hydroxy-5-phenyl-2,3,4,5-tetrahydro-1H-1lambda(6),4-benzothiazepine-1,1-dione	C₂₁H₂₇NO₃S	详情	详情

Extended Information