3-[[4-amino-5-(3,4,5-trimethoxybenzyl)-2-pyrimidinyl]imino]-5-bromo-1,3-dihydro-2H-indol-2-one -Drug Synthesis Database

【结构式】

【分子编号】42593

【品名】3-[[4-amino-5-(3,4,5-trimethoxybenzyl)-2-pyrimidinyl]imino]-5-bromo-1,3-dihydro-2H-indol-2-one

【CA登记号】

【分子式】C₂₂H₂₀BrN₅O₄

【分子量】498.3361

【元素组成】C 53.02% H 4.05% Br 16.03% N 14.05% O 12.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of trimethoprim (I) with 5-bromoisatin (II) in ethanolic HOAc produced the imine adduct (III). Subsequent condensation with norfloxacin (IV) and formaldehyde yielded the title Mannich base.

参考文献中间体

合成目标

【1】 Nath, G.; Pandeya, S.N.; De Clercq, E.; Sriram, D.; Synthesis, antibacterial, antifungal and anti-HIV activities for norfloxacin Mannich bases. Eur J Med Chem 2000, 35, 2, 249.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42591	5-(3,4,5-trimethoxybenzyl)-2,4-pyrimidinediamine; 2-amino-5-(3,4,5-trimethoxybenzyl)-4-pyrimidinylamine	738-70-5	C₁₄H₁₈N₄O₃	详情	详情
(II)	42592	5-bromo-1H-indole-2,3-dione	87-48-9	C₈H₄BrNO₂	详情	详情
(III)	42593	3-[[4-amino-5-(3,4,5-trimethoxybenzyl)-2-pyrimidinyl]imino]-5-bromo-1,3-dihydro-2H-indol-2-one		C₂₂H₂₀BrN₅O₄	详情	详情
(IV)	11290	1-Ethyl-6-fluoro-4-oxo-7-piperazino-1,4-dihydro-3-quinolinecarboxylic acid; Norfloxacin	70458-96-7	C₁₆H₁₈FN₃O₃	详情	详情

Extended Information