【结 构 式】 |
【分子编号】42488 【品名】bromo([(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]piperidinyl]methyl)mercury 【CA登记号】 |
【 分 子 式 】C36H40BrHgNO4 【 分 子 量 】831.21194 【元素组成】C 52.02% H 4.85% Br 9.61% Hg 24.13% N 1.69% O 7.7% |
合成路线1
该中间体在本合成路线中的序号:(V)A new synthesis of miglitol has been reported: Reaction of the bromoglycoside (I) with ethanolamine (II) by means of Zn and NaBH3CN in refluxing propanol/water gives the adduct (III), which is benzylated with benzyl chloride and NaH in DMF yielding compound (IV). The cyclization of (IV) by means of mercury trifluoroacetate in THF, followed by a treatment with KHCO3 and KBr affords a mixture of the diastereomeric organomercuric piperidines (V) and (VI) which are separated by chromatography. The desired diastereomer (VI) was treated with O2 and NaBH4 in DMF to give the protected piperidinemethanol (VII), which is finally debenzylated by hydrogenolysis with H2 over Pd/C in ethanol. The undesired diastereomer (V) can be recovered by Swern oxidation giving aldehyde (VIII), isomerization of (VIII) with DBU to provide aldehyde (IX) and reduction of (IX) to the already reported piperidinemethanol (VII).
【1】 Therisod, M.; Fouacea, S.; Lipophilic prodrugs of 1-deoxynojirimycin derivatives. Tetrahedron Lett 2000, 41, 38, 7313. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 42485 | (2S,3S,4S,5R,6S)-3,4,5-tris(benzyloxy)-2-(bromomethyl)-6-methoxytetrahydro-2H-pyran; benzyl (2S,3R,4S,5S,6S)-4,5-bis(benzyloxy)-6-(bromomethyl)-2-methoxytetrahydro-2H-pyran-3-yl ether | C28H31BrO5 | 详情 | 详情 | |
(II) | 10259 | Ethanol amine;Ethanolamine;2-Aminoethanol; 2-Amino-1-ethanol;2-Aminoethyl alcohol | 141-43-5 | C2H7NO | 详情 | 详情 |
(III) | 42486 | 2-[[(2S,3S,4R)-2,3,4-tris(benzyloxy)-5-hexenyl]amino]-1-ethanol | C29H35NO4 | 详情 | 详情 | |
(IV) | 42487 | N-[2-(benzyloxy)ethyl]-N-[(2S,3S,4R)-2,3,4-tris(benzyloxy)-5-hexenyl]amine; (2S,3S,4R)-2,3,4-tris(benzyloxy)-N-[2-(benzyloxy)ethyl]-5-hexen-1-amine | C36H41NO4 | 详情 | 详情 | |
(V) | 42488 | bromo([(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]piperidinyl]methyl)mercury | C36H40BrHgNO4 | 详情 | 详情 | |
(VI) | 42489 | bromo([(2S,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]piperidinyl]methyl)mercury | C36H40BrHgNO4 | 详情 | 详情 | |
(VII) | 42490 | [(2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]piperidinyl]methanol | C36H41NO5 | 详情 | 详情 | |
(VIII) | 42491 | (2R,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]-2-piperidinecarbaldehyde | C36H39NO5 | 详情 | 详情 | |
(IX) | 42492 | (2S,3R,4R,5S)-3,4,5-tris(benzyloxy)-1-[2-(benzyloxy)ethyl]-2-piperidinecarbaldehyde | C36H39NO5 | 详情 | 详情 |