2-chloro-4-nitrophenylamine; 2-chloro-4-nitroaniline -Drug Synthesis Database

【结构式】

【分子编号】42314

【品名】2-chloro-4-nitrophenylamine; 2-chloro-4-nitroaniline

【CA登记号】121-87-9

【分子式】C₆H₅ClN₂O₂

【分子量】172.57068

【元素组成】C 41.76% H 2.92% Cl 20.54% N 16.23% O 18.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The condensation between 2-chloro-4-nitroaniline (II) and phthalic anhydride (I) in refluxing acetic acid produced phthalimide (III). The nitro group was then reduced to the desired aniline by transfer hydrogenation employing cyclohexene in the presence of Pd/C.

参考文献中间体

合成目标

【1】 Herrenknecht, C.; Maurois, P.; Delcourt, P.; Stables, J.P.; Vamecq, J.; Bac, P.; Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore. J Med Chem 2000, 43, 7, 1311.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11900	2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride	85-44-9	C₈H₄O₃	详情	详情
(II)	42314	2-chloro-4-nitrophenylamine; 2-chloro-4-nitroaniline	121-87-9	C₆H₅ClN₂O₂	详情	详情
(III)	42315	2-(2-chloro-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione		C₁₄H₇ClN₂O₄	详情	详情

Extended Information