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【结 构 式】 
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【分子编号】42308 【品名】ethyl 5-nitro-1-benzofuran-2-carboxylate 【CA登记号】69404-00-8 |
【 分 子 式 】C11H9NO5 【 分 子 量 】235.1962 【元素组成】C 56.17% H 3.86% N 5.96% O 34.01% |
合成路线1
该中间体在本合成路线中的序号：(IX)Vilazodone can be prepared by two related ways: 1) The condensation of indole-5-carbonitrile (I) with 4-chlorobutyryl chloride (II) gives 3-(4-chlorobutyryl)-1H-indole-5-carbonitrile (III), which is reduced with diborane, yielding 3-(4-chlorobutyl)-1H-indole-5-carbonitrile (IV). Reaction of compound (IV) with 5-(1-piperazinyl)benzofuran-2-carboxylic acid (V) affords the expected 1,4-disubstituted piperazine (VI). Finally, the carboxy group of (VI) is converted into the target carboxamide by reaction with 2-chloro-1-methylpyridinium methanesulfonate (CMPM) and ammonia gas. 5-(1-Piperazinyl)benzofuran-2-carboxylic acid (V) is obtained by cyclization of 5-aminobenzofuran-2-carboxylic acid (VII) with bis(2-chloroethyl)amine (VIII). 2) The hydrogenation of 5-nitrobenzofuran-2-carboxylic acid ethyl ester (IX) with H2 and Raney nickel in MeOH gives the corresponding 5-aminobenzofuran compound (X), which is cyclized with bis(2-chloroethyl)amine (VIII) in dichloromethane to afford 5-(1-piperazinyl)benzofuran-2-carboxylic acid ethyl ester (XI). Reaction of compound (XI) with di-tert-butyl dicarbonate in THF provides the protected amine compound 5-[4-(tert-butoxycarbonyl)-1-piperazinyl]benzofuran-2-carboxylic acid ethyl ester (XII), which first is reacted with formamide and sodium alkoxide in N-methylpyrrolidone to provide the corresponding amide (XIII) and then is deprotected by treatment with HCl/MeOH to give 5-(1-piperazinyl)benzofuran-2-carboxamide (XIV). Finally, amide (XIV) is condensed with 3-(4-chlorobutyl)-1H-indole-5-carbonitrile (IV).
| 【1】 Rabasseda, X.; Sorbera, L.A.; Silvestre, J.S.; Castaner, J.; Vilazodone Hydrochloride. Drugs Fut 2001, 26, 3, 247. |
| 【2】 Bottcher, H.; Greiner, H.; Seyfried, C.; Bartoszyk, G. (Merck Patent GmbH); Indole derivs.. DE 4101686; EP 0496222; JP 1992334366; US 5418237 . |
| 【3】 Bottcher, H.; Seyfried, C.; Bartoszyk, G.; Greiner, H. (Merck Patent GmbH); Piperidine and piperazine derivs. which affect the CNS. CA 2133152; DE 4333254; EP 0648767; US 5532241 . |
| 【4】 Bathe, A.; Helfert, B.; Bottcher, H.; Schuster, K. (Merck Patent GmbH); 5-Amino-benzofuran-2-carboxylic acid derivs.. CA 2174494; DE 19514567; EP 0738722; JP 1996291161; US 5723614 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31341 | 5-Cyanoindole; Indole-5-carbonitrile; 1H-Indole-5-carbonitrile | 15861-24-2 | C9H6N2 | 详情 | 详情 |
| (II) | 11265 | 4-Chlorobutanoyl chloride; 4-Chlorobutyric acid chloride | 4635-59-0 | C4H6Cl2O | 详情 | 详情 |
| (III) | 45735 | 3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile | C13H11ClN2O | 详情 | 详情 | |
| (IV) | 45736 | 3-(4-chlorobutyl)-1H-indole-5-carbonitrile | C13H13ClN2 | 详情 | 详情 | |
| (V) | 45737 | 5-(1-piperazinyl)-1-benzofuran-2-carboxylic acid | C13H14N2O3 | 详情 | 详情 | |
| (VI) | 45738 | 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-1-benzofuran-2-carboxylic acid | C26H26N4O3 | 详情 | 详情 | |
| (VII) | 45739 | 5-amino-1-benzofuran-2-carboxylic acid | C9H7NO3 | 详情 | 详情 | |
| (VIII) | 21583 | 2-chloro-N-(2-chloroethyl)-1-ethanamine; Bis(2-chloroethyl)amine; 1,1'-iminobis(2-chloroethane); N,N-bis(2-chloroethyl)amine | 821-48-7 | C4H9Cl2N | 详情 | 详情 |
| (IX) | 42308 | ethyl 5-nitro-1-benzofuran-2-carboxylate | 69404-00-8 | C11H9NO5 | 详情 | 详情 |
| (X) | 45740 | ethyl 5-amino-1-benzofuran-2-carboxylate | C11H11NO3 | 详情 | 详情 | |
| (XI) | 45741 | ethyl 5-(1-piperazinyl)-1-benzofuran-2-carboxylate | C15H18N2O3 | 详情 | 详情 | |
| (XII) | 45742 | tert-butyl 4-[2-(ethoxycarbonyl)-1-benzofuran-5-yl]-1-piperazinecarboxylate | C20H26N2O5 | 详情 | 详情 | |
| (XIII) | 45743 | tert-butyl 4-[2-(aminocarbonyl)-1-benzofuran-5-yl]-1-piperazinecarboxylate | C18H23N3O4 | 详情 | 详情 | |
| (XIV) | 45744 | 5-(1-piperazinyl)-1-benzofuran-2-carboxamide | C13H15N3O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(III)5-Nitrosalicylaldehyde (I) was condensed with diethyl bromomalonate (II) to give ethyl 5-nitrobenzofuran-2-carboxylate (III), which was converted into the corresponding primary amide (IV) by reaction with ethanolic ammonia. Dehydration of amide (IV) to the nitrile (V) was effected by treatment with POCl3. After formation of imidate (VI) with HCl/MeOH, cyclization with ethylenediamine produced the imidazoline (VII). The nitro group of (VII) was then reduced to amine (VIII) using Fe and HCl. This was finally converted to the title isothiocyanate by reaction with thiophosgene.
| 【1】 Hudson, A.L.; Nutt, D.J.; Grundt, P.; Coates, P.A.; Husbands, S.M.; Tyacke, R.; Robinson, E.S.J.; Lewis, J.W.; Probes for imidazole binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett 2000, 10, 6, 605. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42307 | 2-hydroxy-5-nitrobenzaldehyde；5-nitrosalicylaldehyde | 97-51-8 | C7H5NO4 | 详情 | 详情 |
| (II) | 35647 | diethyl 2-bromomalonate | 685-87-0 | C7H11BrO4 | 详情 | 详情 |
| (III) | 42308 | ethyl 5-nitro-1-benzofuran-2-carboxylate | 69404-00-8 | C11H9NO5 | 详情 | 详情 |
| (IV) | 42309 | 5-nitro-1-benzofuran-2-carboxamide | C9H6N2O4 | 详情 | 详情 | |
| (V) | 42310 | 5-nitro-1-benzofuran-2-carbonitrile | C9H4N2O3 | 详情 | 详情 | |
| (VI) | 42311 | methyl 5-nitro-1-benzofuran-2-carboximidoate | C10H8N2O4 | 详情 | 详情 | |
| (VII) | 42312 | 2-(5-nitro-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole | C11H9N3O3 | 详情 | 详情 | |
| (VIII) | 42313 | 2-(4,5-dihydro-1H-imidazol-2-yl)-1-benzofuran-5-amine; 2-(4,5-dihydro-1H-imidazol-2-yl)-1-benzofuran-5-ylamine | C11H11N3O | 详情 | 详情 |