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【结 构 式】 
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【分子编号】42283 【品名】lithium 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole-2-carboxylate 【CA登记号】 |
【 分 子 式 】C16H17LiN2O5 【 分 子 量 】324.26246 【元素组成】C 59.27% H 5.28% Li 2.14% N 8.64% O 24.67% |
合成路线1
该中间体在本合成路线中的序号：(VI)The cyclization of 2-(3,5-dimethoxyphenyl)glyoxal monohydrate (I) with methyl glyoxylic acid (II) and ammonium acetate in acetonitrile gives the aryl imidazole (III), which is protected with dihydrofuran (IV) and Ts-OH, yielding compound (V). The regioselective lithiation of (V) with n-BuLi, followed by reaction with labeled 14CO2 provides the carboxylic acid (VI), which is esterified with MeI and CaO in DMSO to furnish the methyl ester (VII). The reduction of the ester group of (VII) with LiBH4 affords the carbinol (VIII), which is esterified with trichloroacetonitrile (IX) to provide the trichloroacetimidate (X).
| 【1】 Egan, M.A.M.; et al.; Carbon-14 labeling of a potential new immunoregulant agent. J Label Compd Radiopharm 2000, 43, 11, 1095. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22759 | 1-(3,5-dimethoxyphenyl)-2,2-dihydroxy-1-ethanone | C10H12O5 | 详情 | 详情 | |
| (II) | 15618 | 2-Oxoacetic acid; Glyoxylic Acid | 298-12-4 | C2H2O3 | 详情 | 详情 |
| (III) | 42281 | 4-(3,5-dimethoxyphenyl)-1H-imidazole; 3-(1H-imidazol-4-yl)-5-methoxyphenyl methyl ether | C11H12N2O2 | 详情 | 详情 | |
| (IV) | 22766 | 2,3-dihydrofuran | 1191-99-7 | C4H6O | 详情 | 详情 |
| (V) | 42282 | 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole; 3-methoxy-5-(1-tetrahydro-2-furanyl-1H-imidazol-4-yl)phenyl methyl ether | C15H18N2O3 | 详情 | 详情 | |
| (VI) | 42283 | lithium 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole-2-carboxylate | C16H17LiN2O5 | 详情 | 详情 | |
| (VI) | 45345 | lithium 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole-2-carboxylate | C16H17LiN2O5 | 详情 | 详情 | |
| (VII) | 22767 | methyl 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole-2-carboxylate | C17H20N2O5 | 详情 | 详情 | |
| (VII) | 45346 | methyl 4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazole-2-carboxylate | C17H20N2O5 | 详情 | 详情 | |
| (VIII) | 22768 | [4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazol-2-yl]methanol | C16H20N2O4 | 详情 | 详情 | |
| (VIII) | 45347 | [4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazol-2-yl]methanol | C16H20N2O4 | 详情 | 详情 | |
| (IX) | 42279 | 2,2,2-trichloroacetonitrile; Trichloromethylcyanide | 545-06-2 | C2Cl3N | 详情 | 详情 |
| (X) | 22769 | [4-(3,5-dimethoxyphenyl)-1-tetrahydro-2-furanyl-1H-imidazol-2-yl]methyl 2,2,2-trichloroethanimidoate | C18H20Cl3N3O4 | 详情 | 详情 |