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【结 构 式】

【分子编号】42229

【品名】(1R,5R,13R,17S)-4-(cyclopropylmethyl)-17-ethoxy-10-hydroxy-13-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one

【CA登记号】

【 分 子 式 】C23H29NO4

【 分 子 量 】383.4876

【元素组成】C 72.04% H 7.62% N 3.65% O 16.69%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(I)

The title indolomorphinan derivative was synthesized by Fisher indole synthesis from the known 14-O-ethyl-5-methylnaltrexone (I) and phenylhydrazine hydrochloride (II) in refluxing acetic acid, followed by conversion to the corresponding hydrochloride salt.

1 Helv Chim Acta 1993, 76, 476.
2 Schmidhammer, H. (AstraZeneca plc); New antagonist cpds.. EP 0759922; JP 1998500131; US 6136817; WO 9531463 .
3 Monory, K.; Daurer, D.; Schmidhammer, H.; Borsodi, A.; Wieser, M.; Traynor, J.R.; Elliott, J.; Synthesis and biological evaluation of 14-alkoxymorphinans. 14. 14-Ethoxy-5-methyl substituted indolomorphinans with delta opioid receptor selectivity. Bioorg Med Chem Lett 1997, 7, 2, 151.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 42229 (1R,5R,13R,17S)-4-(cyclopropylmethyl)-17-ethoxy-10-hydroxy-13-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one C23H29NO4 详情 详情
(II) 11818 Phenyl hydrazine; 1-Phenylhydrazine 100-63-0 C6H8N2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(I)

A further procedure for the preparation of (I) from naltrexone (III) has been reported. Naltrexone (III) was O-alkylated with diethyl sulfate in the presence of NaH to give (IV). Deprotonation of (IV) using the combination potassium tert-butoxide/butyllithium, followed by methylation with dimethyl sulfate, yielded the 5-methyl derivative (V). The aryl- and enol ether groups of (V) were then cleaved by means of concentrated HBr.

1 Krassing, R.; et al.; A novel method for the introduction of a 5-beta-methyl group into 4,5-alpha-epoxymorphinan-6-ones via the enol ether. Helv Chim Acta 2000, 83, 2, 380.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 42229 (1R,5R,13R,17S)-4-(cyclopropylmethyl)-17-ethoxy-10-hydroxy-13-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one C23H29NO4 详情 详情
(III) 42232 (1S,5R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10-trien-14-one C20H23NO4 详情 详情
(IV) 42230 (1S,5R,17S)-4-(cyclopropylmethyl)-10,14,17-triethoxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,14-tetraene; (1S,5R)-4-(cyclopropylmethyl)-10,14-diethoxy-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,14-tetraen-17-yl ethyl ether C26H35NO4 详情 详情
(V) 42231 (1R,5R,13R,17S)-4-(cyclopropylmethyl)-10,14,17-triethoxy-13-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,14-tetraene; (1R,5R,13R)-4-(cyclopropylmethyl)-10,14-diethoxy-13-methyl-12-oxa-4-azapentacyclo[9.6.1.0(1,13).0(5,17).0(7,18)]octadeca-7(18),8,10,14-tetraen-17-yl ethyl ether C27H37NO4 详情 详情
Extended Information