methyl (2S,3R,4S,5R,6R)-3,4,5-tris(acetoxy)-6-hydroxytetrahydro-2H-pyran-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】42148

【品名】methyl (2S,3R,4S,5R,6R)-3,4,5-tris(acetoxy)-6-hydroxytetrahydro-2H-pyran-2-carboxylate

【CA登记号】

【分子式】C₁₃H₁₈O₁₀

【分子量】334.27992

【元素组成】C 46.71% H 5.43% O 47.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Protected glucuronic acid (I) was converted to trichloroacetimidate (II) by treatment with trichloroacetonitrile and Cs2CO3.

【1】 Yumibe, N.P.; Alton, K.B.; Van Heek, M.; Davis, H.R.; Vaccaro, W.D. (Schering Corp.); Sugar-substd. 2-azetidinones useful as hypocholesterolemic agents. EP 0877750; JP 1998512592; WO 9716455 .
【2】 Yumibe, N.P.; Alton, K.B.; Vaccaro, W.D.; Davis, H.R.; Van Heek, M. (Schering Corp.); Sugar-substd. 2-azetidinones useful as hypocholesterolemic agents. US 5756470 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	42148	methyl (2S,3R,4S,5R,6R)-3,4,5-tris(acetoxy)-6-hydroxytetrahydro-2H-pyran-2-carboxylate		C₁₃H₁₈O₁₀	详情	详情
(II)	42149	methyl (2S,3R,4S,5R,6S)-3,4,5-tris(acetoxy)-6-[(2,2,2-trichloroethanimidoyl)oxy]tetrahydro-2H-pyran-2-carboxylate		C₁₅H₁₈Cl₃NO₁₀	详情	详情

Extended Information