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【结 构 式】 
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【分子编号】42119 【品名】hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one 【CA登记号】 |
【 分 子 式 】C7H12N2O 【 分 子 量 】140.18516 【元素组成】C 59.98% H 8.63% N 19.98% O 11.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Horner-Emmons condensation of 1,4-dibenzyl-2-piperazinecarboxaldehyde (I) with phosphonate (II) gave piperazineacrylate (III). Subsequent double bond hydrogenation and hydrogenolysis of the benzyl groups of (III) produced the spontaneous cyclization of the resulting amino ester to furnish the diazabicyclononanone (IV). Finally, condensation of amine (IV) with p-fluorobenzenesulfonyl chloride (V) yielded the title sulfonamide.
| 【1】 Manetti, D.; et al.; Design, synthesis, and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents. J Med Chem 2000, 43, 10, 1969. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 42117 | 1,4-dibenzyl-2-piperazinecarbaldehyde | C19H22N2O | 详情 | 详情 | |
| (II) | 27698 | methyl 2-(diethoxyphosphoryl)acetate | 1067-74-9 | C7H15O5P | 详情 | 详情 |
| (III) | 42118 | methyl (E)-3-(1,4-dibenzyl-2-piperazinyl)-2-propenoate | C22H26N2O2 | 详情 | 详情 | |
| (IV) | 42119 | hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one | C7H12N2O | 详情 | 详情 | |
| (V) | 12292 | 4-Fluorobenzenesulfonyl chloride | 349-88-2 | C6H4ClFO2S | 详情 | 详情 |
Extended Information