【结 构 式】 |
【分子编号】42082 【品名】2-bromo-1-(2-fluorophenyl)-1-propanone 【CA登记号】 |
【 分 子 式 】C9H8BrFO 【 分 子 量 】231.0643232 【元素组成】C 46.78% H 3.49% Br 34.58% F 8.22% O 6.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)The partial hydrolysis of malonodinitrile (I) with HCl in ethanol gives 2-cyanoacetamide (II), which is treated with ammonia in ethanol to yield 3,3-diaminopropenenitrile (III). Finally, this compound is cyclized with 2-bromo-1-(2-fluorophenyl)-1-propanone (IV) by means of TEA in ethanol.
【1】 Tsuda, M.; et al.; Studies on potassium channel openers: Synthesis and pharmacological properties of novel pyrrole derivatives. 20th Symp Med Chem (Dec 6 2000, Tokyo) 2000, Abst 2P-24. |
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