• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】42028

【品名】methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-5-[formyl(hydroxy)amino]pentanoate

【CA登记号】

【 分 子 式 】C15H20N2O6

【 分 子 量 】324.33368

【元素组成】C 55.55% H 6.22% N 8.64% O 29.6%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

Synthesis of intermediate (XVI): The reaction of the nitrone (XIII) first with hydroxylamine and then with formic acid gives hydroxamate (XIV), which is protected with 2-(trimethylsilylethoxymethyl chloride (A), DIEA and DMAP in CH2Cl2 to affords the protected ester (XV). Finally the methyl ester group of (XV) is hydrolyzed with NaOH in THF/water to afford the acid intermediate (XVI).

1 Yokokawa, F.; et al.; Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete. Tetrahedron 2000, 56, 19, 3027.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 42027 ((4R)-4-[[(benzyloxy)carbonyl]amino]-5-methoxy-5-oxopentyl)(1-methylethylidene)ammoniumolate C17H24N2O5 详情 详情
(XIV) 42028 methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-5-[formyl(hydroxy)amino]pentanoate C15H20N2O6 详情 详情
(XV) 27243 [2-(chloromethoxy)ethyl](trimethyl)silane 76513-69-4 C6H15ClOSi 详情 详情
(XVI) 42029 methyl (12R)-12-[[(benzyloxy)carbonyl]amino]-8-formyl-2,2-dimethyl-5,7-dioxa-8-aza-2-silatridecan-13-oate C21H34N2O7Si 详情 详情
(XVII) 42030 (12R)-12-[[(benzyloxy)carbonyl]amino]-8-formyl-2,2-dimethyl-5,7-dioxa-8-aza-2-silatridecan-13-oic acid C20H32N2O7Si 详情 详情
Extended Information