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【结 构 式】 
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【分子编号】42028 【品名】methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-5-[formyl(hydroxy)amino]pentanoate 【CA登记号】 |
【 分 子 式 】C15H20N2O6 【 分 子 量 】324.33368 【元素组成】C 55.55% H 6.22% N 8.64% O 29.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Synthesis of intermediate (XVI): The reaction of the nitrone (XIII) first with hydroxylamine and then with formic acid gives hydroxamate (XIV), which is protected with 2-(trimethylsilylethoxymethyl chloride (A), DIEA and DMAP in CH2Cl2 to affords the protected ester (XV). Finally the methyl ester group of (XV) is hydrolyzed with NaOH in THF/water to afford the acid intermediate (XVI).
| 【1】 Yokokawa, F.; et al.; Total synthesis of amamistatin A, an antiproliferative linear peptide from an actinomycete. Tetrahedron 2000, 56, 19, 3027. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIII) | 42027 | ((4R)-4-[[(benzyloxy)carbonyl]amino]-5-methoxy-5-oxopentyl)(1-methylethylidene)ammoniumolate | C17H24N2O5 | 详情 | 详情 | |
| (XIV) | 42028 | methyl (2R)-2-[[(benzyloxy)carbonyl]amino]-5-[formyl(hydroxy)amino]pentanoate | C15H20N2O6 | 详情 | 详情 | |
| (XV) | 27243 | [2-(chloromethoxy)ethyl](trimethyl)silane | 76513-69-4 | C6H15ClOSi | 详情 | 详情 |
| (XVI) | 42029 | methyl (12R)-12-[[(benzyloxy)carbonyl]amino]-8-formyl-2,2-dimethyl-5,7-dioxa-8-aza-2-silatridecan-13-oate | C21H34N2O7Si | 详情 | 详情 | |
| (XVII) | 42030 | (12R)-12-[[(benzyloxy)carbonyl]amino]-8-formyl-2,2-dimethyl-5,7-dioxa-8-aza-2-silatridecan-13-oic acid | C20H32N2O7Si | 详情 | 详情 |
Extended Information