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【结 构 式】 
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【分子编号】42015 【品名】dibutyl 3-[(isobutoxycarbonyl)[(4-methoxybenzyl)oxy]amino]propylphosphonate 【CA登记号】 |
【 分 子 式 】C24H42NO7P 【 分 子 量 】487.573782 【元素组成】C 59.12% H 8.68% N 2.87% O 22.97% P 6.35% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Isobutyl N-hydroxycarbamate (IX) was O-alkylated with 4-methoxybenzyl bromide (X) using NaOEt to give (XI). Subsequent N-alkylation with 1,3-dibromopropane (IV) produced bromide (XII), which was condensed with the sodium salt of dibutyl phosphonate (XIII) to furnish adduct (XIV). Acid hydrolysis of (XIV) then gave intermediate (VIII).
| 【1】 Takeno, H.; Hemmi, K.; Hashimoto, M.; Kamiya, T. (Fujisawa Pharmaceutical Co., Ltd.); Hydroxyaminohydrocarbonphosphonic acids. DE 2733658; US 4182758; US 4206156 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 12581 | 1,3-Dibromopropane | 109-64-8 | C3H6Br2 | 详情 | 详情 |
| (VIII) | 39088 | 3-(hydroxyamino)propylphosphonic acid | C3H10NO4P | 详情 | 详情 | |
| (IX) | 42012 | isobutyl hydroxycarbamate | C5H11NO3 | 详情 | 详情 | |
| (X) | 27490 | 1-(bromomethyl)-4-methoxybenzene | C8H9BrO | 详情 | 详情 | |
| (XI) | 42013 | isobutyl (4-methoxybenzyl)oxycarbamate | C13H19NO4 | 详情 | 详情 | |
| (XII) | 42014 | isobutyl 3-bromopropyl[(4-methoxybenzyl)oxy]carbamate | C16H24BrNO4 | 详情 | 详情 | |
| (XIII) | 39090 | dibutyl phosphonate | 1809-19-4 | C8H19O3P | 详情 | 详情 |
| (XIV) | 42015 | dibutyl 3-[(isobutoxycarbonyl)[(4-methoxybenzyl)oxy]amino]propylphosphonate | C24H42NO7P | 详情 | 详情 |
Extended Information