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【结 构 式】 
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【分子编号】42006 【品名】3,5-difluoro-4-hydroxybenzonitrile 【CA登记号】2967-54-6 |
【 分 子 式 】C7H3F2NO 【 分 子 量 】155.1037664 【元素组成】C 54.21% H 1.95% F 24.5% N 9.03% O 10.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Nitration of 2,6-difluorophenol (I) gave 2,6-difluoro-4-nitrophenol (II), which was reduced to the corresponding aniline (III) by hydrogenation over Pd/C. Nitrile (IV) was obtained by diazotization of (III) followed by in situ displacement of the diazonium salt with CuCN and KCN. The nitrile (IV) was finally reduced to the title benzylamine employing borane in THF.
| 【1】 Qiu, J.; Stevenson, S.H.; O'Beirne, M.J.; Silverman, R.B.; 2,6-Difluorophenol as a bioisostere of a carboxylic acid: Bioisosteric analogues of gamma-aminobutyric acid. J Med Chem 1999, 42, 2, 329. |
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