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【结 构 式】 
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【分子编号】41611 【品名】4-bromophenyl isocyanate; 1-bromo-4-isocyanatobenzene 【CA登记号】2493-02-9 |
【 分 子 式 】C7H4BrNO 【 分 子 量 】198.0189 【元素组成】C 42.46% H 2.04% Br 40.35% N 7.07% O 8.08% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The title urea derivative was synthesized by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 4-bromophenyl isocyanate (II) in refluxing ethanol.
| 【1】 Matsuno, K.; Ichimura, M.; Nakajima, T.; Tahara, K.; Fujiwara, S.; Kase, H.; Ushiki, J.; Giese, N.A.; Pandey, A.; Scarborough, R.M.; Lokker, N.A.; Yu, J.C.; Irie, J.; Tsukuda, E.; Ide, S.-i; Oda, S.; Nomoto, Y.; Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem 2002, 45, 14, 3057. |
| 【2】 Matsuno, K.; Ichimura, M.; Nomoto, Y.; Fujiwara, S.; Ide, S.; Tsukuda, E.; Irie, J.; Oda, S. (Kyowa Hakko Kogyo Co., Ltd.); Nitrogenous heterocyclic cpds. EP 0882717; WO 9814431 . |
Extended Information