2-amino-9-([2-[(8-methyl-4H-1,3,2-benzodioxaphosphinin-2-yl)oxy]ethoxy]methyl)-1,9-dihydro-6H-purin-6-one -Drug Synthesis Database

【结构式】

【分子编号】41609

【品名】2-amino-9-([2-[(8-methyl-4H-1,3,2-benzodioxaphosphinin-2-yl)oxy]ethoxy]methyl)-1,9-dihydro-6H-purin-6-one

【CA登记号】

【分子式】C₁₆H₁₈N₅O₅P

【分子量】391.323382

【元素组成】C 49.11% H 4.64% N 17.9% O 20.44% P 7.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of acyclovir (I) with the cyclic chlorophosphane (II) in the presence of N,N-diisopropyl ethylamine afforded the acyclovir phosphite ester (III). This was then oxidized to the target phosphate using tert-butyl hydroperoxide.

参考文献中间体

合成目标

【1】 Meier, C.; Habel, L.; Haller-Meier, F.; Lomp, A.; Herderich, M.; Klöcking, R.; Meerbach, A.; Wutzler, P.; Chemistry and anti-herpes simplex virus type 1 evaluation of cycloSal-nucleotides of acyclic nucleoside analogues. Antivir Chem Chemother 1998, 9, 389.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28279	2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one	59277-89-3	C₈H₁₁N₅O₃	详情	详情
(II)	41608	2-chloro-8-methyl-4H-1,3,2-benzodioxaphosphinine		C₈H₈ClO₂P	详情	详情
(III)	41609	2-amino-9-([2-[(8-methyl-4H-1,3,2-benzodioxaphosphinin-2-yl)oxy]ethoxy]methyl)-1,9-dihydro-6H-purin-6-one		C₁₆H₁₈N₅O₅P	详情	详情

Extended Information