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【结 构 式】 
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【分子编号】41588 【品名】 【CA登记号】 |
【 分 子 式 】C24H21N5O5S 【 分 子 量 】491.52744 【元素组成】C 58.65% H 4.31% N 14.25% O 16.28% S 6.52% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The known dichloropyrimidine derivative (I) was condensed with 2-phenylethenesulfonamide (II) in the presence of NaH in DMF to furnish the N-pyrimidinylsulfonamide (III). Displacement of the remaining chlorine of (III) by means of methanolic NaOMe provided the corresponding methyl ether (IV). The title potassium salt was then prepared by treatment of sulfonamide (IV) with ethanolic KOH.
| 【1】 Harada, H.; Kazami, J.; Watanuki, S.; Tsuzuki, R.; Sudou, K.; Tanaka, A. (Yamanouchi Pharmaceutical Co., Ltd.); Arylethenesulfonamide derivs. and drug compsn. containing the same. EP 0882719; US 6083955; WO 9722595 . |
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