N-[(Z)-4-pyridinylmethylidene]-3-pyridinamine; N-(3-pyridinyl)-N-[(Z)-4-pyridinylmethylidene]amine -Drug Synthesis Database

【结构式】

【分子编号】41431

【品名】N-[(Z)-4-pyridinylmethylidene]-3-pyridinamine; N-(3-pyridinyl)-N-[(Z)-4-pyridinylmethylidene]amine

【CA登记号】

【分子式】C₁₁H₉N₃

【分子量】183.21268

【元素组成】C 72.11% H 4.95% N 22.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The intermediate secondary amine (IV) was prepared by condensation of 3-aminopyridine (I) with isonicotinic aldehyde (II), followed by catalytic hydrogenation of the resulting imine (III).

参考文献中间体

合成目标

【1】 Kubota, H.; Suzumura, K.; Suzuki, T.; Ohmizu, H.; Kashimura, Y.; Antioxidative property of T-0970, a new ureidophenol derivative. Free Radical Research 2000, 32, 3, 255.
【2】 Suzuki, T.; Ohmizu, H.; Hashimura, Y.; Kubota, H.; Tanaka, K. (Tanabe Seiyaku Co., Ltd.); Phenol-derivs. having pharmaceutical activity and process for preparing the same. EP 0790240; JP 1998195037; US 5849732 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33327	3-Pyridinylamine; 3-Aminopyridine; 3-Pyridinamine	462-08-8	C₅H₆N₂	详情	详情
(II)	17203	4-Pyridinecarboxaldehyde; isonicotinaldehyde	872-85-5	C₆H₅NO	详情	详情
(III)	41431	N-[(Z)-4-pyridinylmethylidene]-3-pyridinamine; N-(3-pyridinyl)-N-[(Z)-4-pyridinylmethylidene]amine		C₁₁H₉N₃	详情	详情
(IV)	41432	N-(3-pyridinyl)-N-(4-pyridinylmethyl)amine; N-(4-pyridinylmethyl)-3-pyridinamine		C₁₁H₁₁N₃	详情	详情

Extended Information