8-chloro-4-[(E)-(dimethylamino)methylidene]-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one -Drug Synthesis Database

【结构式】

【分子编号】41392

【品名】8-chloro-4-[(E)-(dimethylamino)methylidene]-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one

【CA登记号】

【分子式】C₁₉H₁₆ClFN₂O

【分子量】342.8000232

【元素组成】C 66.57% H 4.7% Cl 10.34% F 5.54% N 8.17% O 4.67%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The known benzazepinone (I) was reacted with dimethylformamide dimethylacetal in DMF to furnish enamino ketone (II). Subsequent cyclization of (II) with guanidine in the presence of sodium methoxide produced the title pyrimido-benzazepine.

参考文献中间体

合成目标

【1】 Trybulski, E.J.; et al.; 2-Benzazepines. 5.Synthesis of pyrimido[5,4-d][2] benzazepines and their evaluation as anxiolytic agents. J Med Chem 1983, 26, 11, 1589.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	41391	8-chloro-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one		C₁₆H₁₁ClFNO	详情	详情
(II)	41392	8-chloro-4-[(E)-(dimethylamino)methylidene]-1-(2-fluorophenyl)-3,4-dihydro-5H-2-benzazepin-5-one		C₁₉H₁₆ClFN₂O	详情	详情
(III)	14790	Guanidine	113-00-8	CH₅N₃	详情	详情

Extended Information