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【结 构 式】 
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【分子编号】41285 【品名】N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide 【CA登记号】 |
【 分 子 式 】C45H54N8O10 【 分 子 量 】866.97168 【元素组成】C 62.34% H 6.28% N 12.92% O 18.45% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of the cyclopeptide analogue (I) with morpholine (II) and formaldehyde by means of MsOH in hot methanol gives the 4-morpholinylmethyl derivative (III), which by a treatment with NaOAc in hot acetic acid yields the methylene derivative (IV). Finally this compound is condensed with quinuclidine-3(S)-thiol in hot acetone.
| 【1】 Bastart, J.P.; Paris, J.M.; Radisson, X. (Aventis SA); Pristinaymcin IA or viginiamycin derivs. and their preparation. EP 0432029 . |
| 【2】 Barriere, J.C.; Paris, J.M.; RP 59500 and related semisynthetic streptogramins. Drugs Fut 1993, 18, 9, 833. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IIIa) | 41286 | C50H63N9O11 | 详情 | 详情 | ||
| (IIIb) | 41287 | C50H63N9O11 | 详情 | 详情 | ||
| (I) | 41285 | N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide | C45H54N8O10 | 详情 | 详情 | |
| (II) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
| (IV) | 41288 | C46H54N8O10 | 详情 | 详情 | ||
| (V) | 41289 | (3S)-1-azabicyclo[2.2.2]octane-3-thiol; (3S)-1-azabicyclo[2.2.2]oct-3-ylhydrosulfide | 4595-82-8 | C7H13NS | 详情 | 详情 |
Extended Information