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【结 构 式】

【分子编号】41285

【品名】N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide

【CA登记号】

【 分 子 式 】C45H54N8O10

【 分 子 量 】866.97168

【元素组成】C 62.34% H 6.28% N 12.92% O 18.45%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The condensation of the cyclopeptide analogue (I) with morpholine (II) and formaldehyde by means of MsOH in hot methanol gives the 4-morpholinylmethyl derivative (III), which by a treatment with NaOAc in hot acetic acid yields the methylene derivative (IV). Finally this compound is condensed with quinuclidine-3(S)-thiol in hot acetone.

1 Bastart, J.P.; Paris, J.M.; Radisson, X. (Aventis SA); Pristinaymcin IA or viginiamycin derivs. and their preparation. EP 0432029 .
2 Barriere, J.C.; Paris, J.M.; RP 59500 and related semisynthetic streptogramins. Drugs Fut 1993, 18, 9, 833.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IIIa) 41286   C50H63N9O11 详情 详情
(IIIb) 41287   C50H63N9O11 详情 详情
(I) 41285 N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide C45H54N8O10 详情 详情
(II) 10388 Morpholine 110-91-8 C4H9NO 详情 详情
(IV) 41288   C46H54N8O10 详情 详情
(V) 41289 (3S)-1-azabicyclo[2.2.2]octane-3-thiol; (3S)-1-azabicyclo[2.2.2]oct-3-ylhydrosulfide 4595-82-8 C7H13NS 详情 详情
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