4-[(2-isopropyl-1-indolizinyl)sulfonyl]phenol -Drug Synthesis Database

【结构式】

【分子编号】41267

【品名】4-[(2-isopropyl-1-indolizinyl)sulfonyl]phenol

【CA登记号】

【分子式】C₁₇H₁₇NO₃S

【分子量】315.39292

【元素组成】C 64.74% H 5.43% N 4.44% O 15.22% S 10.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

This compound has been obtained by two similar ways: 1) The alkylation of 4-hydroxyphenyl(2-isopropylindolizin-1-yl)sulfone (I) 1,3-dibromopropane (II) by means of K2CO3 in DMF gives 4-(3-bromopropoxy)phenyl(2-isopropylindolizin-1-yl)sulfone (III), which is finally condensed with N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine. 2) By direct condensation of sulfone (I) with the tertiary amine N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine.

参考文献中间体

合成目标

【1】 Gubin, J.; et al.; A novel class of calcium-entry blockers: The 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines. J Med Chem 1992, 35, 6, 981.
【2】 Gubin, J.; et al.; Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(Aminoalkoxy)phenyl]sulfonyl]indolizines. J Med Chem 1993, 36, 10, 1425.
【3】 Chatelain, P.; Gubin, J.; Aminoalkoxybenzenesulfonyl heterocyclic compounds, a novel class of calcium channel antagonists. Structure-activity relationship with a focus on fantofarone, SR 33557. Drugs Fut 1993, 18, 9, 817.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	41267	4-[(2-isopropyl-1-indolizinyl)sulfonyl]phenol		C₁₇H₁₇NO₃S	详情	详情
(II)	12581	1,3-Dibromopropane	109-64-8	C₃H₆Br₂	详情	详情
(III)	41268	4-(3-bromopropoxy)phenyl 2-isopropyl-1-indolizinyl sulfone; 1-[[4-(3-bromopropoxy)phenyl]sulfonyl]-2-isopropylindolizine		C₂₀H₂₂BrNO₃S	详情	详情
(IV)	29986	3-chloro-N-(3,4-dimethoxyphenethyl)-N-methyl-1-propanamine; N-(3-chloropropyl)-N-(3,4-dimethoxyphenethyl)-N-methylamine		C₁₄H₂₂ClNO₂	详情	详情
(V)	18938	2-(3,4-dimethoxyphenyl)-N-methyl-1-ethanamine; N-(3,4-dimethoxyphenethyl)-N-methylamine	3490-06-0	C₁₁H₁₇NO₂	详情	详情

Extended Information