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【结 构 式】

【分子编号】41262

【品名】 

【CA登记号】

【 分 子 式 】C18H37Br2O3P

【 分 子 量 】492.271742

【元素组成】C 43.92% H 7.58% Br 32.46% O 9.75% P 6.29%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The reaction of hexadecanol (I) with the cyclic chlorophosphate ester (II) and DIEA in dichloromethane gives the cyclic hexadecyl phosphate (III), which is brominated with Br2 in the same solvent to yield the mixed 2-bromoethyl hexadecyl bromophosphate ester (IV). Finally this compound is condensed with trimethylamine in acetonitrile/isopropanol/chloroform to furnish the target phosphorylcholine ester.

1 Bittman, R.; Lohmeyer, M.; Antitumor ether lipids and alkylphosphocholines. Drugs Fut 1994, 19, 11, 1021.
2 Reddy, K.C.; Byun, H.S.; Bittman, R.; Antitumor ether lipids: An improved synthesis of ilmofosine and an enantioselective synthesis of an ilmofosine analog. Tetrahedron Lett 1994, 35, 17, 2679.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23090 1-hexadecanol 36653-82-4 C16H34O 详情 详情
(II) 41260 2-chloro-1,3,2-dioxaphospholane 822-39-9 C2H4ClO2P 详情 详情
(III) 41261 2-(hexadecyloxy)-1,3,2-dioxaphospholane C18H37O3P 详情 详情
(IV) 41262   C18H37Br2O3P 详情 详情
Extended Information