【结 构 式】 |
【分子编号】41225 【品名】[(3R)-5-(benzyloxy)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl]methanol 【CA登记号】 |
【 分 子 式 】C21H26O3 【 分 子 量 】326.43564 【元素组成】C 77.27% H 8.03% O 14.7% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(R)-(VII)The enantiomers of the title product have been obtained by optical resolution of the racemic hydroxymethyl compound (rac)-(VII) by means of "Candida cylindracea" and vinyl acetate to give (S)-(VII) and (R)-(VII). Finally both chiral intermediates are condensed with 1-methylpiperazine (IX) and debenzylated by hydrogenation with H2 over Pd/C in ethanol/HOAc for the racemic mixture (rac)-(VII).
【1】 Petty, M.A.; Marciniak, G.; Design and biological evaluation of new antioxidants for use in cerebrovascular disorders. Drugs Fut 1996, 21, 10, 1037. |
【2】 Ayers, T.A.; Schnettler, R.A.; Marciniak, G.; Krysan, D.J. (Hoechst Marion Roussel Inc.); Novel process for preparing derivatives of 2,2,4,6,7-pentaalkyl-2,2-dihydrobenzofuranols. EP 0813530 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(rac)-(VII) | 30773 | [5-(benzyloxy)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl]methanol | C21H26O3 | 详情 | 详情 | |
(S)-(VII) | 41224 | [(3S)-5-(benzyloxy)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl]methanol | C21H26O3 | 详情 | 详情 | |
(R)-(VII) | 41225 | [(3R)-5-(benzyloxy)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl]methanol | C21H26O3 | 详情 | 详情 | |
(IX) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |
Extended Information