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【结 构 式】 
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【分子编号】41152 【品名】5-hexen-1-ol 【CA登记号】821-41-0 |
【 分 子 式 】C6H12O 【 分 子 量 】100.16068 【元素组成】C 71.95% H 12.08% O 15.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Cycloaddition of 5-hexen-1-ol (I) with (II) in presence of NaHCO3 yields isoxazoline (III). Alternatively (III) can be obtained by treatment of (I) with diethyl nitromalonate (A) in mesitylene. Isoxazoline (III) is then oxidized by means of Jones reagent to provide acid (IV) which is coupled in presence of BOP with the imidazole derivative (V) and hydrolyzed with LiOH affording derivative (VI). Acid (VI) is coupled with derivative (IX) (obtained by reaction of diaminopropionate (VII) with (VIII) in presence of DIEA) by means of BOP, and finally hydrolyzed to afford the desired product.
| 【1】 Withyak, J.; Pitts, W.J.; Smallheer, J.M.; et al.; Isoxazolines as potent antagonists of the integrin alphavbeta3. J Med Chem 2000, 43, 1, 27. |
| 【2】 Voss, M.E.; Jadhav, P.K.; Smallheer, J.M.; Batt, D.G.; Pitts, W.J.; Wityak, J. (DuPont Pharmaceuticals Co.); Isoxazoline and isoxazole derivs. as integrin receptor antagonists. EP 0828737; JP 1999506436; US 5710159; WO 9637492 . |
| 【3】 Jadhav, P.; Repta, A.J.; Pitts, W.J.; Hussain, M.A.; Batt, D.G. (DuPont Pharmaceuticals Co.); Heterocyclic integrin inhibitor prodrugs. WO 9843962 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 41159 | diethyl 2-nitromalonate | C7H11NO6 | 详情 | 详情 | |
| (I) | 41152 | 5-hexen-1-ol | 821-41-0 | C6H12O | 详情 | 详情 |
| (II) | 30424 | 2-ethoxy-N-hydroxy-2-oxoethanimidoyl chloride | 14337-43-0 | C4H6ClNO3 | 详情 | 详情 |
| (III) | 41153 | ethyl 5-(4-hydroxybutyl)-4,5-dihydro-3-isoxazolecarboxylate | C10H17NO4 | 详情 | 详情 | |
| (IV) | 41154 | 4-[3-(ethoxycarbonyl)-4,5-dihydro-5-isoxazolyl]butyric acid | C10H15NO5 | 详情 | 详情 | |
| (V) | 41155 | 1H-imidazol-2-ylamine; 1H-imidazol-2-amine; 2-Aminoimidazole | 7720-39-0 | C3H5N3 | 详情 | 详情 |
| (VI) | 41156 | 5-[4-(1H-imidazol-2-ylamino)-4-oxobutyl]-4,5-dihydro-3-isoxazolecarboxylic acid | C11H14N4O4 | 详情 | 详情 | |
| (VII) | 41157 | tert-butyl (2S)-2-amino-3-[(tert-butoxycarbonyl)amino]propanoate | C12H24N2O4 | 详情 | 详情 | |
| (VIII) | 41158 | 2,4,6-trimethylbenzenesulfonyl chloride | 773-64-8 | C9H11ClO2S | 详情 | 详情 |
| (IX) | 36588 | tert-butyl (2S)-3-amino-2-[(mesitylsulfonyl)amino]propanoate | C16H26N2O4S | 详情 | 详情 |
Extended Information