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【结 构 式】 
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【分子编号】40988 【品名】2,6-dibromo-3-methylphenol 【CA登记号】 |
【 分 子 式 】C7H6Br2O 【 分 子 量 】265.93204 【元素组成】C 31.62% H 2.27% Br 60.09% O 6.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)Also 3,5-dibromo-4-hydroxybenzaldehyde (II) is commercially available but it may also be prepared by published procedures: 1) The synthesis can be performed by treating 2,6-dibromophenol (X) with hexamethylenetetramine in acetic acid. 2) Alternatively the synthetic pathway can be the oxidation of 3,5-dibromo-4-hydroxytoluene (XI) by means of DDQ in dioxane with a small amount of water.
| 【1】 McNutt, R.W. Jr.; Hunter, R.N. III; Jung, D.K.; Lackey, K.E.; Dickerson, S.; Harris, P.A.; Veal, J.M.; Peel, M.R. (Glaxo Group Ltd.); Benzylidene-1,3-dihydro-indol-2-one derivs. as receptor tyrosine kinase inhibitors, particularly of Raf kinases. EP 1003721; WO 9910325 . |
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