• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】40838

【品名】methyl (2R)-3-[[tert-butyl(diphenyl)silyl]oxy]-2-methylpropanoate

【CA登记号】

【 分 子 式 】C21H28O3Si

【 分 子 量 】356.53702

【元素组成】C 70.74% H 7.92% O 13.46% Si 7.88%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XXVIII)

The chiral sulfone intermediate (XIV) has been obtained as follows: The silylation of 3-hydroxy-2(R)-methylpropionic acid methyl ester (XXVII) as usual gives the silylated ester (XXVIII), which is reduced to the chiral propanol (XXIX). The reaction of (XXIX) with TsCl and pyridine yields the tosylate (XXX), which is condensed with methyl phenyl sulfone (XXXI) by means of n-BuLi in THF to afford the chiral sulfone (XXXII). Desilylation of (XXXII) with TBAF in THF provides the 4-hydroxy-3-methylbutylsulfone (XXXIII), which is finally resilylated with TBDMS-Cl and imidazole to furnish the target intermediate (XIV).

1 Mulzer, J.; Ohler, E.; Mantoulidis, A. (Schering AG); Method for producing epothilone B and derivs., and intermediate products for this method. WO 0023452 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIV) 40825 tert-butyl(dimethyl)[[(2S)-2-methyl-4-(phenylsulfonyl)butyl]oxy]silane; (3S)-4-[[tert-butyl(dimethyl)silyl]oxy]-3-methylbutyl phenyl sulfone C17H30O3SSi 详情 详情
(XXVII) 14965 methyl 3-hydroxy-2-methylpropanoate; METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE 80657-57-4 C5H10O3 详情 详情
(XXVIII) 40838 methyl (2R)-3-[[tert-butyl(diphenyl)silyl]oxy]-2-methylpropanoate C21H28O3Si 详情 详情
(XXIX) 40839 (2S)-3-[[tert-butyl(diphenyl)silyl]oxy]-2-methyl-1-propanol C20H28O2Si 详情 详情
(XXX) 40840 (2R)-3-[[tert-butyl(diphenyl)silyl]oxy]-2-methylpropyl 4-methylbenzenesulfonate C27H34O4SSi 详情 详情
(XXXI) 23622 methyl phenyl sulfone; methyl(dioxo)phenyl-lambda(6)-sulfane 3112-85-4 C7H8O2S 详情 详情
(XXXII) 40841 (3S)-4-[[tert-butyl(diphenyl)silyl]oxy]-3-methylbutyl phenyl sulfone; tert-butyl[[(2S)-2-methyl-4-(phenylsulfonyl)butyl]oxy]diphenylsilane C27H34O3SSi 详情 详情
(XXXIII) 40842 (2S)-2-methyl-4-(phenylsulfonyl)-1-butanol C11H16O3S 详情 详情
Extended Information