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【结 构 式】 
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【分子编号】40736 【品名】bromo(hexyl)magnesium 【CA登记号】3761-92-0 |
【 分 子 式 】C6H13BrMg 【 分 子 量 】189.37822 【元素组成】C 38.05% H 6.92% Br 42.19% Mg 12.83% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：The required propargyl alcohol (XVIII) was obtained by Swern oxidation of alcohol (XVI) to aldehyde (XVII), followed by condensation with dimethyl(diazomethyl)phosphonate
| 【1】 Ha, J.D.; Cha, J.K.; Total synthesis of clavepictines A and B. Diastereoselective cyclization of delta-aminoallenes. J Am Chem Soc 1999, 121, 43, 10012. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 40736 | bromo(hexyl)magnesium | 3761-92-0 | C6H13BrMg | 详情 | 详情 | |
| (XVI) | 40248 | allyl (2S,3R,6S)-6-[(4R)-5-hydroxy-4-(tetrahydro-2H-pyran-2-yloxy)pentyl]-2-methyl-3-[(triisopropylsilyl)oxy]-1-piperidinecarboxylate | C29H55NO6Si | 详情 | 详情 | |
| (XVII) | 40249 | allyl (2S,3R,6S)-2-methyl-6-[(4R)-5-oxo-4-(tetrahydro-2H-pyran-2-yloxy)pentyl]-3-[(triisopropylsilyl)oxy]-1-piperidinecarboxylate | C29H53NO6Si | 详情 | 详情 | |
| (XVIII) | 40250 | allyl (2S,3R,6S)-6-[(4R)-4-hydroxy-5-hexynyl]-2-methyl-3-[(triisopropylsilyl)oxy]-1-piperidinecarboxylate | C25H45NO4Si | 详情 | 详情 | |
| (XIX) | 40251 | allyl (2S,3R,6S)-6-(8-ethoxy-8-oxo-4,5-octadienyl)-2-methyl-3-[(triisopropylsilyl)oxy]-1-piperidinecarboxylate | C29H51NO5Si | 详情 | 详情 | |
| (XX) | 40252 | allyl (2S,3R,6S)-6-(8-hydroxy-4,5-tetradecadienyl)-2-methyl-3-[(triisopropylsilyl)oxy]-1-piperidinecarboxylate | C33H61NO4Si | 详情 | 详情 | |
| (XXI) | 40253 | 1-hexyl-8-[(2S,5R,6S)-6-methyl-5-[(triisopropylsilyl)oxy]piperidinyl]-3,4-octadienyl triethylsilyl ether; (2S,3R,6S)-2-methyl-6-[8-[(triethylsilyl)oxy]-4,5-tetradecadienyl]-3-[(triisopropylsilyl)oxy]piperidine | C35H71NO2Si2 | 详情 | 详情 | |
| (XXII) | 40254 | (E)-1-[(4S,6S,7R,9aS)-6-methyl-7-[(triisopropylsilyl)oxy]octahydro-2H-quinolizin-4-yl]-1-decen-4-ol | C29H57NO2Si | 详情 | 详情 | |
| (XXIII) | 40255 | (3R,4S,6S,9aS)-6-[(1E,3E)-1,3-decadienyl]-4-methyloctahydro-2H-quinolizin-3-yl triisopropylsilyl ether; (3R,4S,6S,9aS)-6-[(1E,3E)-1,3-decadienyl]-4-methyl-3-[(triisopropylsilyl)oxy]octahydro-2H-quinolizine | C29H55NOSi | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)Coupling of 1,3,5-trichlorobenzene (I) with n-hexylmagnesium bromide (II) produced the corresponding trihexylbenzene (III) (1-3). The title triiodo derivative was then obtained by iodination of (III) with either bis(trifluoroacetoxy)iodobenzene and iodine in CCl4 (1-3) or N-iodosuccinimide in the presence of trifluoromethanesulfonic acid.
| 【1】 Estep, K.G.; et al.; 1,3,5-Trialkyl-2,4,6-triiodobenzenes: Novel X-ray contrast agents for gastrointestinal imaging. J Med Chem 2000, 43, 10, 1940. |
| 【2】 Josef, K.A.; Bacon, E.R.; Estep, K.G.; Baker, E.J.; Toner, J.L.; Illig, C.R.; Douty, B.D.; Lee, R.W. (Sterling Winthrop Inc.); Compsns. of alkylbenzenes and cellulose derivs. for visualization of the gastrointestinal tract. US 5385721 . |
| 【3】 Josef, K.A.; Douty, B.D.; Bacon, E.R.; Illig, C.; Estep, K.G. (Sterling Winthrop Inc.); Compsns. of alkylbenzenes in film-forming materials for visualization of the gastrointestinal tract. EP 0609589; JP 1994234664; US 5334370 . |
Extended Information