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【结 构 式】 
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【分子编号】40611 【品名】(4aS,9aS)-6-ethoxy-2,4a,9-trimethyl-2,3,4,4a,9,9a-hexahydro[1,2]oxazino[6,5-b]indole; (4aS,9aS)-2,4a,9-trimethyl-2,3,4,4a,9,9a-hexahydro[1,2]oxazino[6,5-b]indol-6-yl ethyl ether 【CA登记号】 |
【 分 子 式 】C15H22N2O2 【 分 子 量 】262.35196 【元素组成】C 68.67% H 8.45% N 10.68% O 12.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)An alternative procedure for the preparation of the intermediate geneseroline (III) consisted in the oxidation of eseretole (V) to geneseretole (VI), followed by ether cleavage by means of concentrated sulfuric acid.
| 【1】 Ventura, P.; Pighi, R.; Servadio, V.; Pietra, C.; Amari, G.; Salsi, B.; Pivetti, F.; Delcanale, M.; Chiesi, P.; Villetti, G. (Chiesi Farmaceutici SpA); A process for the preparation of aminocarbonyl derivs. of geneseroline having selective brain anticholinesterase activity. WO 9919329 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 40608 | (4aS,9aS)-2,4a,9-trimethyl-2,3,4,4a,9,9a-hexahydro[1,2]oxazino[6,5-b]indol-6-ol | C13H18N2O2 | 详情 | 详情 | |
| (V) | 40610 | (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl ethyl ether; (3aS,8aR)-5-ethoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole | C15H22N2O | 详情 | 详情 | |
| (VI) | 40611 | (4aS,9aS)-6-ethoxy-2,4a,9-trimethyl-2,3,4,4a,9,9a-hexahydro[1,2]oxazino[6,5-b]indole; (4aS,9aS)-2,4a,9-trimethyl-2,3,4,4a,9,9a-hexahydro[1,2]oxazino[6,5-b]indol-6-yl ethyl ether | C15H22N2O2 | 详情 | 详情 |
Extended Information