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【结 构 式】 
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【分子编号】40603 【品名】silver(1+) bis(benzyloxy)(oxo)phosphoranolate 【CA登记号】 |
【 分 子 式 】C14H14AgO4P 【 分 子 量 】385.104722 【元素组成】C 43.66% H 3.66% Ag 28.01% O 16.62% P 8.04% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：Esterification of alcohol (XXXII) with either 4-bromobutyric acid and DCC or 4-bromobutyryl chloride gave rise to bromoester (XL). Then displacement of the bromine atom of (XL) with silver dibenzylphosphate yielded phosphate ester (XLI). The title compound was then obtained by hydrogenolysis of the benzyl ester groups of (XLI) over Pd/C.
| 【1】 Girijavallabhan, V.M.; et al.; Sch 59884, a water-soluble prodrug of Sch 56592 for intravenous formulations. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999, Abst F1932. |
| 【2】 Bennett, F.; Girijavallabhan, V.M.; Patel, N.M.; Ganguly, A.; Saksena, A.K. (Schering Corp.); Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent. EP 1027349; WO 9915522 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 40603 | silver(1+) bis(benzyloxy)(oxo)phosphoranolate | C14H14AgO4P | 详情 | 详情 | ||
| 40604 | 4-bromobutyric acid | 2623-87-2 | C4H7BrO2 | 详情 | 详情 | |
| 40605 | 4-bromobutanoyl chloride | 927-58-2 | C4H6BrClO | 详情 | 详情 | |
| (XXXII) | 34850 | 4-[4-[4-(4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydro-3-furanyl]methoxy]phenyl)-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one | C37H42F2N8O4 | 详情 | 详情 | |
| (XL) | 34854 | (1S,2S)-2-(4-[4-[4-(4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydro-3-furanyl]methoxy]phenyl)-1-piperazinyl]phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-1-methylbutyl 4-bromobutanoate | C41H47BrF2N8O5 | 详情 | 详情 | |
| (XLI) | 34855 | (1S,2S)-2-(4-[4-[4-(4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)tetrahydro-3-furanyl]methoxy]phenyl)-1-piperazinyl]phenyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-1-methylbutyl 4-[[bis(benzyloxy)phosphoryl]oxy]butanoate | C55H61F2N8O9P | 详情 | 详情 |
Extended Information