【结 构 式】 |
【分子编号】40523 【品名】4-[(2-isopropoxyethoxy)methyl]phenyl 2-oxiranylmethyl ether; 2-([4-[(2-isopropoxyethoxy)methyl]phenoxy]methyl)oxirane 【CA登记号】 |
【 分 子 式 】C15H22O4 【 分 子 量 】266.33728 【元素组成】C 67.65% H 8.33% O 24.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)The condensation of 4-hydroxybenzyl alcohol (I) with 2-isopropoxyethanol (II) by heating at 150 C gives the corresponding benzyl ether (III), which is condensed with epichlorohydrin (IV) to yield the adduct (V). Finally, this compound is treated with isopropylamine in ethanol.
【1】 Schliep, H.-J.; Enenkel, H.-J.; Minck, K.; Becker, K.-H.; Jonas, R. (Merck Patent GmbH); Phenoxy-amino-propanols. US 4258062 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 29474 | 4-(hydroxymethyl)phenol; 4-hydroxyphenylmethanol 4-hydroxybenzenemethanol; 4-Hydroxybenzyl alcohol | 623-05-2 | C7H8O2 | 详情 | 详情 |
(II) | 23938 | 2-isopropoxy-1-ethanol | 109-59-1 | C5H12O2 | 详情 | 详情 |
(III) | 40522 | 4-[(2-isopropoxyethoxy)methyl]phenol | C12H18O3 | 详情 | 详情 | |
(IV) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
(V) | 40523 | 4-[(2-isopropoxyethoxy)methyl]phenyl 2-oxiranylmethyl ether; 2-([4-[(2-isopropoxyethoxy)methyl]phenoxy]methyl)oxirane | C15H22O4 | 详情 | 详情 | |
(VI) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information