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【结 构 式】 
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【分子编号】40472 【品名】2-(4-cyanophenoxy)-5-methoxybenzoic acid 【CA登记号】 |
【 分 子 式 】C15H11NO4 【 分 子 量 】269.25668 【元素组成】C 66.91% H 4.12% N 5.2% O 23.77% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)The condensation of 2-bromo-5-methoxybenzoic acid (IX) with 4-hydroxybenzonitrile (X) by means of K2CO3, Cu and Cu2I2 in n-pentanol gives 2-(4-cyanophenoxy)-5-methoxybenzoic acid (XI), which is cyclized and hydrolyzed with hot H2SO4 to give the starting product (I). Alternatively, compound (XI) can be cyclized and partially hydrolyzed with hot polyphosphoric acid giving 7-methoxy-9-oxoxanthene-2-carboxamide (XII), which is finally hydrolyzed with H2SO4.
| 【1】 Castaner, J.; Blancafort, P.; AH 7725. Drugs Fut 1976, 1, 7, 313. |
| 【2】 Bays, D.E.; Xanthone derivatives.. DE 2058295; FR 2073425; GB 1312620; US 3706768 . |
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