5,8-dihydro-1-naphthalenyl 2-oxiranylmethyl ether; 2-[(5,8-dihydro-1-naphthalenyloxy)methyl]oxirane -Drug Synthesis Database

【结构式】

【分子编号】40444

【品名】5,8-dihydro-1-naphthalenyl 2-oxiranylmethyl ether; 2-[(5,8-dihydro-1-naphthalenyloxy)methyl]oxirane

【CA登记号】

【分子式】C₁₃H₁₄O₂

【分子量】202.25296

【元素组成】C 77.2% H 6.98% O 15.82%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

By reaction of 5,8-dihydro-1-(2,3-epoxypropoxy)naphthalene (V) with tertbutylamine (B) to give 5,8-dihydro-1-[2-hydroxy-3-(tertbutylamino)propoxy]naphthalene (VI), followed by oxidation of the double bond with silver acetate and I2 in acetic acid.

参考文献中间体

合成目标

【1】 Hanck, F.P.; et al.; Naphthalene derivatives. CA 1041544; DE 2421549; FR 2236489; GB 1464950; JP 50018449 .
【2】 Weetman, D.F.; Castaner, J.; Nadolol. Drugs Fut 1976, 1, 9, 434.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	17895	2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine	75-64-9	C₄H₁₁N	详情	详情
(V)	40444	5,8-dihydro-1-naphthalenyl 2-oxiranylmethyl ether; 2-[(5,8-dihydro-1-naphthalenyloxy)methyl]oxirane		C₁₃H₁₄O₂	详情	详情
(VI)	40445	1-(tert-butylamino)-3-(5,8-dihydro-1-naphthalenyloxy)-2-propanol		C₁₇H₂₅NO₂	详情	详情

Extended Information