N-[(4S)-4-amino-5-oxopentyl]-N'-[(4-methoxyphenyl)(diphenyl)methyl]guanidine -Drug Synthesis Database

【结构式】

【分子编号】40423

【品名】N-[(4S)-4-amino-5-oxopentyl]-N'-[(4-methoxyphenyl)(diphenyl)methyl]guanidine

【CA登记号】

【分子式】C₂₆H₃₀N₄O₂

【分子量】430.54996

【元素组成】C 72.53% H 7.02% N 13.01% O 7.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVI)

The intermediate argininol derivative (XIV) has been obtained by condensation of N-omega(4-methoxytrityl)-L-argininal (XVI) with benzothiazole (XVII) by means of n-BuLi in ethyl ether.

参考文献中间体

合成目标

【1】 Nakanishi, H.; Ogbu, C.O.; Shea, J.P.; Cao, B.; Kahn, M.; Boatman, P.D.; Kim, H.-O.; Eguchi, M.; Secondary structure peptide mimetics: Design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors. J Med Chem 1999, 42, 8, 1367.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XIV)	40421	N-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-hydroxypentyl]-N'-[(4-methoxyphenyl)(diphenyl)methyl]guanidine		C₃₃H₃₅N₅O₂S	详情	详情
(XVI)	40423	N-[(4S)-4-amino-5-oxopentyl]-N'-[(4-methoxyphenyl)(diphenyl)methyl]guanidine		C₂₆H₃₀N₄O₂	详情	详情
(XVII)	36784	1,3-benzothiazole	95-16-9	C₇H₅NS	详情	详情

Extended Information