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【结 构 式】 
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【分子编号】45107 【品名】 【CA登记号】 |
【 分 子 式 】C13H12N2O2 【 分 子 量 】228.25056 【元素组成】C 68.41% H 5.3% N 12.27% O 14.02% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IIa)The preparation of radiolabeled (I), needed for biological and pharmacological studies, was accomplished by yet another synthesis. Here, the high yielding synthesis of (IIa) was utilized to prepare labeled (IIa) from chloronicotinic acid and U-14C aniline. This was then condensed with (VIII) to produce radiolabeled (I). This process minimized the handling and workup of radiolabeled materials. The mechanistic aspects for the development of this synthesis have been described recently.
| 【1】 Blythin, D.J.; Gala, D.; Pirodomast < Prop INN >. Drugs Fut 1991, 16, 12, 1099. |
| 【2】 Gala, D.; Duelfer, T.; A short synthesis and its application to the preparation of radiolabelled leukotriene inhibitor Sch 37224. J Label Compd Radiopharm 1991, 29, 6, 651-6. |
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