[(6R,7S)-7-methoxy-8-oxo-2-([[3-(tributylstannyl)benzyl]amino]carbonyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl acetate -Drug Synthesis Database

【结构式】

【分子编号】43151

【品名】[(6R,7S)-7-methoxy-8-oxo-2-([[3-(tributylstannyl)benzyl]amino]carbonyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl acetate

【CA登记号】

【分子式】C₃₀H₄₆N₂O₅SSn

【分子量】665.48172

【元素组成】C 54.15% H 6.97% N 4.21% O 12.02% S 4.82% Sn 17.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

The synthesis of the 125I-labeled compound is shown in Scheme 2. Carboxylic acid (IV) was coupled with 3-(tri-n-butylstannyl)benzylamine (VIII) via the mixed anhydride (V) to produce amide (IX). Subsequent oxidation with oxone afforded the sulfone (X). Finally, iododestannylation of (X) employing Na125I and chloramine-T furnished the radiolabeled compound.

参考文献中间体

合成目标

【1】 Garnes, K.T.; et al.; Preparation of 3-125I-benzyl-(6R,7S9-7-methoxy-3-acetoxymethyl-3-cephem-4-carboxamide-1,1-dioxide. J Label Compd Radiopharm 1999, 42, 1, 77.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IV)	43147	(6R,7S)-3-[(acetoxy)methyl]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	C₁₁H₁₃NO₆S	详情	详情
(V)	43148		C₁₄H₁₇NO₈S	详情	详情
(VIII)	43150	3-(tributylstannyl)benzylamine; [3-(tributylstannyl)phenyl]methanamine	C₁₉H₃₅NSn	详情	详情
(IX)	43151	[(6R,7S)-7-methoxy-8-oxo-2-([[3-(tributylstannyl)benzyl]amino]carbonyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl acetate	C₃₀H₄₆N₂O₅SSn	详情	详情
(X)	43152	[(6R,7S)-7-methoxy-5,5,8-trioxo-2-([[3-(tributylstannyl)benzyl]amino]carbonyl)-5lambda(6)-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl acetate	C₃₀H₄₆N₂O₇SSn	详情	详情

Extended Information