2,2-dichloro-N-[2-(3-chlorobenzoyl)phenyl]acetamide -Drug Synthesis Database

【结构式】

【分子编号】40185

【品名】2,2-dichloro-N-[2-(3-chlorobenzoyl)phenyl]acetamide

【CA登记号】

【分子式】C₁₅H₁₀Cl₃NO₂

【分子量】342.60804

【元素组成】C 52.59% H 2.94% Cl 31.04% N 4.09% O 9.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 2-amino-3'-chlorobenzophenone (I) with dichloroacetyl chloride (II) in acetone gives o-(m'-chlorobenzoyl)-2,2-dichloroacetanilide (III), which is cyclized with potassium cyanide in water yielding 2-amino-3-(m-chlorophenyl-3H-indol-3-ol (IV). Finally, this compound is condensed with 1,3-dibromopropane (A) in refluxing ethanol.

参考文献中间体

合成目标

【1】 White, A.C.; Bell, S.C. (John Wyeth & Brother Ltd.); Process for the preparation of diazepino[1,2-a]indoles. CH 590286; DE 2417917; FR 2247227; GB 1427066; US 3931226 .
【2】 Weetman, D.F.; Castaner, J.; Ciclazindol. Drugs Fut 1977, 2, 8, 508.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	12581	1,3-Dibromopropane	109-64-8	C₃H₆Br₂	详情	详情
(I)	40184	(2-aminophenyl)(3-chlorophenyl)methanone		C₁₃H₁₀ClNO	详情	详情
(II)	17829	2,2-dichloroacetyl chloride; dichloroacetyl chloride	79-36-7	C₂HCl₃O	详情	详情
(III)	40185	2,2-dichloro-N-[2-(3-chlorobenzoyl)phenyl]acetamide		C₁₅H₁₀Cl₃NO₂	详情	详情
(IV)	40186	2-amino-3-(3-chlorophenyl)-3H-indol-3-ol		C₁₄H₁₁ClN₂O	详情	详情

Extended Information