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【结 构 式】

【分子编号】40059

【品名】(4-methoxy-2,3,6-trimethylbenzyl)(triphenyl)phosphonium chloride

【CA登记号】

【 分 子 式 】C29H30ClOP

【 分 子 量 】460.983062

【元素组成】C 75.56% H 6.56% Cl 7.69% O 3.47% P 6.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The chloromethylation of 2,3,5-trimethylanisole (II) [prepared by alkylation of 2,3,5-trimethylphenol (I) with methyl iodide] with formaldehyde and HCl gives 4-chloromethyl-2,3,5-trimethylanisole (III), which by reaction with triphenylphosphine in refluxing toluene affords 4-methoxy-2,3,6-trimethylbenzyltriphenylphosphonium chloride (IV). The Wittig reaction of (IV) with ethyl 7-formyl-3-methylocta-2,4,6-trien-1-oate (A) affords the desired compound.

1 Castaner, J.; Thorpe, P.; RO 10/9359. Drugs Fut 1977, 2, 3, 199.
2 Bollag, W. et al.; Polyene derivatives. DE 2414619; ES 424750; FR 2223037; GB 1468401; GB 1468402 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 40060 ethyl (2E,4E,6E)-3,7-dimethyl-8-oxo-2,4,6-octatrienoate C12H16O3 详情 详情
(I) 33479 2,3,5-trimethylphenol 697-82-5 C9H12O 详情 详情
(II) 33480 1-methoxy-2,3,5-trimethylbenzene; methyl 2,3,5-trimethylphenyl ether 20469-61-8 C10H14O 详情 详情
(III) 40058 4-(chloromethyl)-2,3,5-trimethylphenyl methyl ether; 2-(chloromethyl)-5-methoxy-1,3,4-trimethylbenzene C11H15ClO 详情 详情
(IV) 40059 (4-methoxy-2,3,6-trimethylbenzyl)(triphenyl)phosphonium chloride C29H30ClOP 详情 详情
Extended Information