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【结 构 式】 
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【分子编号】40049 【品名】6-amino-4-(2,4-dichlorophenoxy)-2-imino-1(2H)-pyrimidinol 【CA登记号】 |
【 分 子 式 】C10H8Cl2N4O2 【 分 子 量 】287.10468 【元素组成】C 41.83% H 2.81% Cl 24.7% N 19.51% O 11.15% |
合成路线1
该中间体在本合成路线中的序号：(IV)Compound can be prepared in tvvo different ways both starting from 2,4-diamino-6-chloropyrimidine (I): 1) The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine. 2) A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.
| 【1】 Hyde, T.J.; N-Alkyl pyrrolidone-plasticized copolylactam compositions. US 3644264 . |
| 【2】 Anthony, W.C.; et al.; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines. CH 495361; DE 1795837; FR 1510017; GB 1167736; US 3382247; US 3382248; US 3461461 . |
| 【3】 Castaner, J.; Sungurbey, J.; Minoxidil. Drugs Fut 1977, 2, 6, 383. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10158 | Piperidine | 110-89-4 | C5H11N | 详情 | 详情 | |
| (A) | 40047 | 2,4-dichlorophenol | 120-83-2 | C6H4Cl2O | 详情 | 详情 |
| (I) | 40045 | 2-amino-6-chloro-4-pyrimidinylamine; 6-chloro-2,4-pyrimidinediamine; 4-chloro-2,6-diaminopyrimidine | 156-83-2 | C4H5ClN4 | 详情 | 详情 |
| (II) | 40046 | 6-amino-4-chloro-2-imino-1(2H)-pyrimidinol | C4H5ClN4O | 详情 | 详情 | |
| (III) | 40048 | 6-(2,4-dichlorophenoxy)-2,4-pyrimidinediamine; 2-amino-6-(2,4-dichlorophenoxy)-4-pyrimidinylamine | C10H8Cl2N4O | 详情 | 详情 | |
| (IV) | 40049 | 6-amino-4-(2,4-dichlorophenoxy)-2-imino-1(2H)-pyrimidinol | C10H8Cl2N4O2 | 详情 | 详情 |