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【结 构 式】

【分子编号】40049

【品名】6-amino-4-(2,4-dichlorophenoxy)-2-imino-1(2H)-pyrimidinol

【CA登记号】

【 分 子 式 】C10H8Cl2N4O2

【 分 子 量 】287.10468

【元素组成】C 41.83% H 2.81% Cl 24.7% N 19.51% O 11.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Compound can be prepared in tvvo different ways both starting from 2,4-diamino-6-chloropyrimidine (I): 1) The oxidation of (I) with m-chloroperbenzoic acid in alcohol gives 6-amino-4-chloro-1,2-dihydro-1-hydroxy-2-iminopyrimidine (II), which is then condensed with refluxing piperidine. 2) A mixture of (I), 2,4-dichlorophenol (A) and KOH was heated at 150 C to give 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine (III), which is oxidized with m-chloroperbenzoic acid in alcohol giving 6-amino-4-(2,4-dichlorophenoxy)-1,2-dihydro-1-hydroxy-2-iminopyrimidine (IV). Finally, this product is treated with piperidine at 150 C.

1 Hyde, T.J.; N-Alkyl pyrrolidone-plasticized copolylactam compositions. US 3644264 .
2 Anthony, W.C.; et al.; 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines. CH 495361; DE 1795837; FR 1510017; GB 1167736; US 3382247; US 3382248; US 3461461 .
3 Castaner, J.; Sungurbey, J.; Minoxidil. Drugs Fut 1977, 2, 6, 383.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
10158 Piperidine 110-89-4 C5H11N 详情 详情
(A) 40047 2,4-dichlorophenol 120-83-2 C6H4Cl2O 详情 详情
(I) 40045 2-amino-6-chloro-4-pyrimidinylamine; 6-chloro-2,4-pyrimidinediamine; 4-chloro-2,6-diaminopyrimidine 156-83-2 C4H5ClN4 详情 详情
(II) 40046 6-amino-4-chloro-2-imino-1(2H)-pyrimidinol C4H5ClN4O 详情 详情
(III) 40048 6-(2,4-dichlorophenoxy)-2,4-pyrimidinediamine; 2-amino-6-(2,4-dichlorophenoxy)-4-pyrimidinylamine C10H8Cl2N4O 详情 详情
(IV) 40049 6-amino-4-(2,4-dichlorophenoxy)-2-imino-1(2H)-pyrimidinol C10H8Cl2N4O2 详情 详情
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