(1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-amine; (1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-ylamine -Drug Synthesis Database

【结构式】

【分子编号】39868

【品名】(1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-amine; (1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-ylamine

【CA登记号】

【分子式】C₁₅H₂₂N₂

【分子量】230.35316

【元素组成】C 78.21% H 9.63% N 12.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

The nitration of 2,5,9-trimethyl-6,7-benzomorphane (XII) gives the 2'-nitro derivative (XIII), which by hydrogenation is converted into the corresponding 2'-amino compound (XIV). Finally, this compound is diazotized and converted into the hydroxy compound (V), already obtained.

参考文献中间体

合成目标

【1】 Atsumi, T.; et al.; JP 7343352 .
【2】 Castaner, J.; Paton, D.M.; ID-1229. Drugs Fut 1978, 3, 4, 298.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(V)	39859	(1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-ol	C₁₅H₂₁NO	详情	详情
(XII)	39866	(1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-triene	C₁₅H₂₁N	详情	详情
(XIII)	39867	(1R,9R,13R)-1,10,13-trimethyl-4-nitro-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-triene	C₁₅H₂₀N₂O₂	详情	详情
(XIV)	39868	(1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-amine; (1R,9R,13R)-1,10,13-trimethyl-10-azatricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-4-ylamine	C₁₅H₂₂N₂	详情	详情

Extended Information